2026-06-03 マサチューセッツ大学アマースト校
＜関連情報＞
- https://www.umass.edu/news/article/umass-amherst-researchers-combine-bacteria-and-viruses-demonstrate-new-way-fight
- https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00256-9
サルモネラベクターは、固形腫瘍を縮小させ、抗腫瘍免疫記憶を形成する新規パルボウイルスを生成する Salmonella vector creates de novo parvovirus that reduces solid tumors and forms antitumor immune memory
Shradha Khanduja ∙ Vishnu Raman ∙ Christopher L. Hall ∙ Lars M. Howell ∙ Nele Van Dessel ∙ Neil S. Forbes
Cell Reports Medicine Published:June 3, 2026
DOI:https://doi.org/10.1016/j.xcrm.2026.102839
Highlights
- Engineered Salmonella preserves H-1PV hairpin structures required for virion formation
- Engineered Salmonella safely colonizes and delivers functional virus in tumors in vivo
- Virus-delivering Salmonella (VDS) reduces tumors beyond standard of care or virus alone
- VDS activates innate and adaptive immunity, generating durable antitumor immune memory
Summary
We have created a Salmonella vector that delivers oncolytic viruses (OVs) into solid tumors. Despite their potential, OVs are cleared after systemic injection and are not effective against internal tumors. When injected intravenously, virus-delivering Salmonella (VDS) is safe and colonizes tumors 50 million times more than clearance organs. After colonization, VDS invades cancer cells, releases a virus-encoding plasmid, and initiates virion formation. Bacterial delivery of the H-1 parvovirus reduces both hepatocellular and pancreatic tumors, increases survival, and triggers the formation of tumor-specific splenocytes that prevent re-implantation. Treating with VDS increases dendritic cells, infiltration of CD8 T cells, and polarized macrophages. Intravenous injection of VDS produces the same responses as an intratumoral injection, and outperforms direct injection of H-1 parvovirus (H-1PV), which minimally affects immune responses and tumor volume. Combining bacteria and OVs creates a therapy that activates the immune system, generates antitumor immunity, and provides a promising platform for treating solid tumors.
