COVIDの繰り返しは初感染よりリスクが高いことが判明(Repeat COVID is riskier than first infection, study finds)


2022-11-10 ワシントン大学セントルイス

再感染者は、COVIDに1回だけ感染した人に比べて、死亡リスクが2倍以上、入院リスクが3倍以上となった。また、肺、心臓、血液、腎臓、糖尿病、精神衛生、骨と筋肉、神経障害などのリスクも高かったと、Nature Medicine誌に報告された。


SARS-CoV-2再感染に伴う急性期および急性期以降の後遺症について Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Benjamin Bowe,Yan Xie & Ziyad Al-Aly
Nature Medicine  Published:10 November 2022

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First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Whether reinfection adds to risks incurred after first infection is unclear. Here we used the US Department of Veterans Affairs’ national healthcare database to build a cohort of individuals with one SARS-CoV-2 infection (n = 443,588), reinfection (two or more infections, n = 40,947) and a noninfected control (n = 5,334,729). We used inverse probability-weighted survival models to estimate risks and 6-month burdens of death, hospitalization and incident sequelae. Compared to no reinfection, reinfection contributed additional risks of death (hazard ratio (HR) = 2.17, 95% confidence intervals (CI) 1.93–2.45), hospitalization (HR = 3.32, 95% CI 3.13–3.51) and sequelae including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental health, musculoskeletal and neurological disorders. The risks were evident regardless of vaccination status. The risks were most pronounced in the acute phase but persisted in the postacute phase at 6 months. Compared to noninfected controls, cumulative risks and burdens of repeat infection increased according to the number of infections. Limitations included a cohort of mostly white males. The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase. Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention.