2023-10-24 ニューサウスウェールズ大学(UNSW)
◆この材料は、簡単なペプチドから作られており、生体内の細胞が自然な組織内に存在しているかのように振る舞う生体活性を持ち、また、抗菌作用があるため、医療分野で有用とされています。また、この材料は自己修復能力を持ち、3Dバイオプリンティングや医療用注射材料として理想的です。
◆この発見は、動物由来の材料に代わる倫理的な選択肢としての可能性を秘めており、医療研究などさまざまな分野で活用される可能性があります。今後の研究は、Trpzipゲルを組織培養でどれだけ役立つかを検証し、3Dバイオプリンティングや幹細胞の注入など、その特性を活かす応用を探ることです。
<関連情報>
- https://newsroom.unsw.edu.au/news/science-tech/mimics-human-tissue-fights-bacteria-new-biomaterial-hits-sweet-spot
- https://www.nature.com/articles/s41467-023-41907-1
トリプトファンジッパーペプチドを階層的に集合させ、ストレスを緩和する生理活性ハイドロゲルを開発 Hierarchical assembly of tryptophan zipper peptides into stress-relaxing bioactive hydrogels
Ashley K. Nguyen,Thomas G. Molley,Egi Kardia,Sylvia Ganda,Sudip Chakraborty,Sharon L. Wong,Juanfang Ruan,Bethany E. Yee,Jitendra Mata,Abhishek Vijayan,Naresh Kumar,Richard D. Tilley,Shafagh A. Waters &Kristopher A. Kilian
Nature Communications Published:23 October 2023
DOI:https://doi.org/10.1038/s41467-023-41907-1
Abstract
Soft materials in nature are formed through reversible supramolecular assembly of biological polymers into dynamic hierarchical networks. Rational design has led to self-assembling peptides with structural similarities to natural materials. However, recreating the dynamic functional properties inherent to natural systems remains challenging. Here we report the discovery of a short peptide based on the tryptophan zipper (trpzip) motif, that shows multiscale hierarchical ordering that leads to emergent dynamic properties. Trpzip hydrogels are antimicrobial and self-healing, with tunable viscoelasticity and unique yield-stress properties that allow immediate harvest of embedded cells through a flick of the wrist. This characteristic makes Trpzip hydrogels amenable to syringe extrusion, which we demonstrate with examples of cell delivery and bioprinting. Trpzip hydrogels display innate bioactivity, allowing propagation of human intestinal organoids with apical-basal polarization. Considering these extensive attributes, we anticipate the Trpzip motif will prove a versatile building block for supramolecular assembly of soft materials for biotechnology and medicine.
