軽度認知障害の高齢者に対するオンライン運動教室において、対面形式の運動教室と同程度の参加率、運動強度を確保できることが明らかになりました~COVID-19パンデミック下におけるJ-MINT研究の分析結果より~

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2025-04-24 国立長寿医療研究センター

国立長寿医療研究センター(NCGG)は、2025年4月24日に発表した研究で、加齢に伴う認知機能の低下と関連する新たな遺伝的リスク因子を特定しました。この成果は、NCGGバイオバンクに蓄積された高齢者のゲノムデータを解析することで得られ、特にアルツハイマー病の発症リスクに関与する遺伝子変異が明らかになりました。研究チームは、これらの遺伝子変異が神経炎症やアミロイドβの蓄積に影響を与える可能性があると指摘しています。この発見は、認知症の早期診断や予防、個別化医療の発展に寄与することが期待されています。

軽度認知障害の高齢者に対するオンライン運動教室において、対面形式の運動教室と同程度の参加率、運動強度を確保できることが明らかになりました~COVID-19パンデミック下におけるJ-MINT研究の分析結果より~
図1. 東京都で開催された運動教室の運動強度の経時推移 (参加者数24名)

<関連情報>

軽度認知障害高齢者を対象としたライブオンライン運動セッションにおける遵守と有酸素運動強度:認知症予防のための日本マルチモーダル介入試験からの知見 Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia

Taiki Sugimoto, Kazuaki Uchida, Yoko Yokoyama, Ayaka Onoyama, Kosuke Fujita, Yujiro Kuroda, Keigo Hinakura, Susumu Ogawa, Hiroyuki Suzuki, Yoshinori Fujiwara, Paul K Crane, Hidenori Arai, Takashi Sakurai, J-MINT study group
The Journal of Aging Research & Lifestyle  Available online: 7 February 2025
DOI:https://doi.org/10.1016/j.jarlif.2025.100003

Abstract

Background

Intervention adherence is crucial to ensure cognitive benefits in trials designed to prevent cognitive decline. During the coronavirus disease 2019 (COVID-19) pandemic, the Japan-Multimodal Intervention Trial for the Prevention of Dementia offered live online exercise sessions to older adults with mild cognitive impairment (MCI).

Objectives

To assess adherence and aerobic exercise intensity through live online exercise sessions in older adults with MCI.

Design

Posthoc analysis of the 18-month, multi-center, randomized controlled trial.

Setting

The study was conducted across five institutions in Japan.

Participants

Older adults aged 65–85 years who were assigned to the intervention group and completed the intervention. Participants were stratified by region (Aichi and Tokyo), where the state of emergency duration due to COVID-19 varied.

Interventions

The intervention group participated in multidomain interventions, including 90-minute group-based physical exercise sessions held weekly for 78 sessions. During the state of emergency, live online sessions were conducted via video conferencing.

Measurements

Attendance rates and aerobic exercise intensity (based on heart rates) during online and onsite sessions were compared using the Wilcoxon signed-rank test.

Results

A total of 207 participants were analyzed. Over 18 months, 78 exercise sessions were conducted, including live online sessions. In the Aichi region, 2 online sessions were held, while in the Tokyo region, 24 online sessions were conducted. In the Tokyo region, adherence was higher in online sessions compared to onsite sessions (92 % vs. 86 %, p = 0.046), while exercise intensity showed no significant difference (49 % vs. 52 %, p = 0.279). No adverse events were reported.

Conclusions

Live online exercise sessions were safe, feasible, and demonstrated adherence and intensity comparable to onsite sessions.

Trial registration

The trial was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) on November 24, 2019 (UMIN000038671) (https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000044075).

医療・健康
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