2026-05-26 東京科学大学
図1. 眼科受診したレトロウイルス感染者の臨床像の比較
＜関連情報＞
- https://www.isct.ac.jp/ja/news/wxxw7lb7zm3h
- https://www.ijidonline.com/article/S1201-9712(26)00367-X/fulltext
東京におけるレトロウイルス感染症の眼科患者における特徴的な眼症状と全身症状：HTLV-1とHIVの比較 Distinct ocular and systemic profiles in ophthalmic patients with retrovirus infection in Tokyo: A comparison of HTLV-1 and HIV
Mingming Yang ∙ Yuan Zong ∙ Yaru Zou ∙ Jing Zhang ∙ Kyoko Ohno-Matsui ∙ Koju Kamoi
International Journal of Infectious Diseases Published:April 21, 2026
DOI:https://doi.org/10.1016/j.ijid.2026.108732
Highlights
- HTLV-1 was often first identified through ophthalmic presentation, whereas HIV was usually diagnosed before ocular disease.
- Coinfections, particularly opportunistic infections and syphilis, were more common in ophthalmic patients with HIV.
- Systemic diseases, especially autoimmune disorders, were more common in ophthalmic patients with HTLV-1.
- Targeted HTLV-1 testing should be considered in uveitis of unknown etiology in endemic settings.
Abstract
Objectives
To compare ocular manifestations, coinfections, and systemic disease profiles between ophthalmic patients with HIV infection and those with HTLV-1 infection.
Methods
This retrospective cohort study reviewed medical records from January 2012 through August 2023 at a single tertiary ophthalmology center in Tokyo. Ophthalmic patients with confirmed HIV infection or HTLV-1 infection were included. Ocular manifestations, coinfections, and systemic diseases were compared between the two groups.
Results
HTLV-1 uveitis was the predominant ocular diagnosis in the HTLV-1 group (79 of 91 eyes, 87%), whereas cytomegalovirus retinitis was the most frequent ocular diagnosis in the HIV group (7 of 30 eyes, 23%). Coinfections were more common in the HIV group than in the HTLV-1 group (74% vs 25%; adjusted odds ratio [aOR], 28.8; 95% confidence interval [CI], 4.3-285.7; P < 0.001). In contrast, systemic diseases were more common in the HTLV-1 group than in the HIV group (61% vs 17%; aOR, 18.1; 95% CI, 3.35-128.5; P < 0.001).
Conclusions
Ophthalmic patients with HIV and HTLV-1 infection showed distinct ocular and systemic profiles. These findings suggest that HTLV-1 may be underrecognized in ophthalmic practice and support consideration of targeted HTLV-1 testing in uveitis of unknown etiology in endemic settings.
