2026-06-23 ジョンズ・ホプキンス大学（JHU）
＜関連情報＞
- https://hub.jhu.edu/2026/06/23/lab-study-reveals-patterns-of-inheritance-that-defy-mendels-laws/
- https://www.nature.com/articles/s41588-026-02604-z
- https://www.nature.com/articles/s41588-026-02603-0
マウスにおけるDNAメチル化パターンの非メンデル遺伝 Non-Mendelian inheritance of DNA methylation patterns in mice
Adam Davidovich,Danila Cuomo,Hang Su,Sandeep Kambhampati,Qingqing Gong,Alexandra Naron,Rakel Tryggvadottir,Leonard McMillan,Kasper D. Hansen,David W. Threadgill & Andrew P. Feinberg
Nature Genetics Published:20 May 2026
DOI:https://doi.org/10.1038/s41588-026-02604-z
Abstract
Epigenetic mechanisms such as genomic imprinting demonstrate that molecular inheritance can deviate from typical Mendelian patterns. Despite this, the intergenerational inheritance of DNA methylation remains poorly understood. Here we developed a genome-wide approach to study epigenetic inheritance in mice using long-read nanopore sequencing. Using this approach in both liver and muscle, we found that ~93% of autosomal epigenetic inheritance patterns followed Mendel’s laws, primarily driven by cis-acting methylation quantitative trait loci. However, we also identified extensive non-Mendelian inheritance, including emergent epigenetic inheritance patterns, widespread sex-specific DNA methylation patterns localized to the liver, and five seemingly new autosomal and X-linked imprinted genes. Notably, we also report an example of naturally occurring intergenerational paramutation, confirmed over strain-specific transposable elements within Capn11 and highly likely at Vps37c. Overall, an unexpectedly high ~7% of autosomal epigenetic inheritance patterns identified were non-Mendelian, highlighting the importance of epigenetic information in the analysis of inherited traits and disorders.
対立遺伝子特異的メチル化により非メンデル遺伝が明らかになる Allele-specific methylation uncovers non-Mendelian inheritance
Nature genetics Published:21 May 2026
DOI:https://doi.org/10.1038/s41588-026-02603-0
We developed a genome-wide allele-specific methylation framework using long-read sequencing to characterize intergenerational epigenetic inheritance in mice. This framework revealed non-Mendelian inheritance, including emergent epialleles, imprinting events and paramutation, in a non-transgenic mammalian genome.
