2026-07-14 バース大学
＜関連情報＞
- https://www.bath.ac.uk/announcements/plant-based-wound-dressing-fights-infection-before-it-takes-hold/
- https://www.sciencedirect.com/science/article/pii/S2452199X26003580
抗菌性創傷治療のためのバイオベースフランポリアミド製ヤヌス型電界紡糸ナノファイバー膜 Janus electrospun nanofiber membranes from bio-based furan polyamides for antibacterial wound care
Xiang Ding, Naing Tun Thet, Carmelo Herdes, Edward Chaloner, Mikal Negasi, Ioanna Kontou, Maisem Laabei, Ute Jungwirth, Dominic Savage, Muhammad Kamran, Michael Zachariadis, Toby Jenkins, Matthew G. Davidson, Hannah S. Leese
Bioactive Materials Available online: 24 June 2026
DOI:https://doi.org/10.1016/j.bioactmat.2026.06.022
Highlights
- Sustainable Janus nanofiber membranes are fabricated from bio-based furan polyamides.
- Electrospinning amplifies subtle chain-length-dependent wettability differences.
- Asymmetric PA8F/PA10F membranes enable rapid local antibiotic delivery with high cytocompatibility.
- Antibacterial efficacy is validated in biofilm and ex vivo porcine wound models.
Abstract
Early-stage bacterial contamination and rapid biofilm growth are critical barriers to effective wound healing, highlighting the need for dressing materials that enable prompt, localised antibacterial intervention while maintaining cytocompatibility and sustainability. Here, we report a sustainable electrospun Janus nanofiber membrane based on two bio-derived semi-aromatic furan polyamides, poly(octamethylene furanamide) (PA8F) and poly(decamethylene furanamide) (PA10F), for antibacterial wound dressing applications. Although PA8F and PA10F differ only by two methylene units and show modest wettability differences as dense films, electrospinning into nanofiber networks amplifies this subtle molecular contrast into a pronounced, robust wettability asymmetry that enables a Janus dressing architecture without chemical surface modification. Tetracycline was physically dispersed within the hydrophilic PA8F, prior to electrospinning, to localise antibiotic delivery at the wound-material interface. The Janus membrane exhibits uniform, bead-free nanofibrous morphology and pronounced interfacial wettability asymmetry. Molecular dynamics simulations reveal distinct polymer-water interaction behaviours that underpin the experimentally observed hydration contrast between PA8F and PA10F. Drug release studies demonstrate rapid antibiotic availability, reaching ∼20 μg mL−1 in phosphate-buffered saline within 4 h. The Janus membranes achieve ∼1 log and ∼2 log reductions against Pseudomonas aeruginosa and Staphylococcus aureus colony biofilms, respectively, and produce ∼0.5 log bacterial reduction in an ex vivo porcine burn wound infection model. This study establishes the first use of sustainable furan-based semi-aromatic polyamides as electrospun wound dressings and demonstrates how electrospinning-induced asymmetry can translate subtle molecular differences into efficient, localised antibacterial delivery for advanced wound care.
