卵は卵管の中でどうやって運ばれる？ ～卵管の「ひだ構造」の役割の検証に成功

2026-08-04 基礎生物学研究所,総合研究大学院大学

図：マウスとニワトリの卵管内腔面のひだ構造。卵管を管の長軸に沿って切り開き、露出させた内腔面を撮影した。卵巣—子宮軸に沿って走る上皮組織のひだ構造が見られる。

＜関連情報＞

• https://www.nibb.ac.jp/press/2026/08/04.html
• https://www.pnas.org/doi/10.1073/pnas.2605383123

卵管を通る卵母細胞の輸送の成功は、卵管上皮ひだの縦方向の配列に依存しない Successful oocyte transport through the oviduct does not depend on the longitudinal alignment of oviduct epithelial folds

Fumiko Matsukawa Usami, Masaki Arata, Kagayaki Kato, +3 , and Toshihiko Fujimori
Proceedings of the National Academy of Sciences  Published:August 4, 2026
DOI:https://doi.org/10.1073/pnas.2605383123

Abstract

The luminal epithelium of the oviduct exhibits ciliary beating oriented along the ovary–uterus (O–U) axis, driving oocyte transport toward the uterus. Longitudinal epithelial folds have also been proposed to facilitate this transport, but their functional contribution has not been tested because the mechanisms that orient these folds remain unclear. In this study, we found that in Vangl1^gt/gt oviducts, which lack the core planar cell polarity (PCP) protein VANGL1, ciliary beating orientation is largely preserved, whereas longitudinal folds are disrupted. Despite fold malformation, Vangl1^gt/gt females were able to produce offspring, suggesting that oocyte transport to the uterus can occur even when longitudinal fold alignment is disrupted. Polarized distributions of core PCP proteins at cell boundaries have been proposed to establish O–U–oriented ciliary beating and cell elongation, and theoretical work predicts that O–U–aligned cell elongation drives longitudinal fold formation. Consistent with this, our three-dimensional cell-shape analysis revealed a loss of cell elongation in Vangl1^gt/gt oviducts. Moreover, although other core PCP proteins remained polarized, their polarity axes were misaligned with ciliary orientation in Vangl1^gt/gt oviducts, suggesting that ciliary orientation can be guided by mechanisms that are at least partly independent of canonical core-protein polarity. Together, our findings help define the physiological contribution of longitudinal folds and illuminate how distinct polarity systems—fold orientation, cell elongation, and ciliary beating—are established and coordinated in the oviduct.