2026-08-14 清華大学
Working principle and physical demonstration of the glucose-powered bioabsorbable electronic bandage
＜関連情報＞
- https://www.tsinghua.edu.cn/en/info/1245/15008.htm
- https://www.science.org/doi/10.1126/sciadv.aed9445
糖尿病性創傷治癒のためのグルコース駆動型共生生体吸収性包帯による内因性電場の回復 Restoration of endogenous electric fields with a glucose-powered symbiotic bioabsorbable bandage for diabetic wound healing
Lingling Xu, Engui Wang, Ming Ying, Lin Luo, […] , and Han Ouyang
Science Advances Published:10 Jun 2026
DOI:https://doi.org/10.1126/sciadv.aed9445
Abstract
Endogenous electric fields (EFs) are essential for tissue regeneration but are diminished under hyperglycemia conditions, thereby impeding diabetic wound healing. Here, we report a biodegradable, glucose-powered electronic fabric bandage (GEB) that restores wound-edge electrical fields and enables closed-loop wound healing. To avoid compromising clinical applicability, we integrated all components into a soft, lightweight, and breathable bandage design to replace the traditional bulky electrical stimulator design. We also show the universal glucose-powered electricity generation and therapeutic functions of the electronic bandage across species and organs in diabetic wound models. In diabetic mouse wounds, porcine skin defects, and intestinal injury, the bandage uses endogenous glucose for power generation, thereby reducing local glucose levels and restoring the endogenous EF that guided cell migration, reprogrammed macrophage polarization, and promoted angiogenesis, to accelerate wound healing. These findings should establish an “endogenous glucose-powered symbiotic bioelectronics” paradigm for next-generation bioelectronic medicine.
