2026-05-25 エディンバラ大学
＜関連情報＞
- https://www.ed.ac.uk/news/cell-therapy-boost-for-advanced-liver-disease-treatment
- https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(26)00156-6
自己マクロファージ療法は肝硬変患者の移植なし生存率を向上させる：第2相臨床試験の長期追跡調査 Autologous macrophage therapy increases transplant-free survival in cirrhosis: Long-term follow-up of a phase 2 clinical trial
Paul N. Brennan ∙ Alastair M. Kilpatrick ∙ Alison Glover ∙ … ∙ John F. Dillon ∙ Jonathan A. Fallowfield ∙ Stuart J. Forbes
Cell Stem Cell Published:May 25, 2026
DOI:https://doi.org/10.1016/j.stem.2026.04.016
Graphical abstract
Highlights
- Cirrhosis patients were treated with autologous macrophages vs. standard care
- Macrophage-treated patients had significantly prolonged transplant-free survival
- No evidence of increased serious adverse events attributable to macrophage therapy
- Stabilization of proinflammatory cytokines was associated with improved long-term survival
Summary
Liver cirrhosis is a major contributor to global morbidity and mortality, and transplantation remains the only cure for end-stage disease. Preclinical studies have indicated that macrophage injections reduce inflammation, resolve fibrosis, and stimulate liver regeneration. The phase 1/2 Macrophage Therapy for Liver Cirrhosis trial (MATCH01; ISRCTN10368050) demonstrated the safety and potential efficacy of autologous monocyte-derived macrophage therapy in cirrhosis. Following MATCH01, participants were re-enrolled in a long-term follow-up (LTFU) study, extending observation to up to 4 years from randomization. Macrophage-treated patients in MATCH01 phase 2 demonstrated a significantly lower risk of death or transplant within the LTFU period (30.8%) compared with standard medical care (58.3%); macrophage-treated patients had an additional 252 days of restricted mean survival time within the LTFU period. There was no evidence of increased serious adverse events attributable to cell therapy. These results support the continued advancement of macrophage-based regenerative strategies as a promising therapeutic option for end-stage liver disease.
