2026-10-14 テキサスA&M大学
＜関連情報＞
- https://today.tamu.edu/news/2026/10/14/dnas-molecular-sunscreen-offers-clues-to-lifes-origins/
- https://www.pnas.org/doi/abs/10.1073/pnas.2615278123
紫外線による光損傷経路と、初期遺伝子系におけるウラシルよりもチミンが進化的に選択された理由 UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems
Keyvan Khosh Abady, Negar Karpourazar, and Peter M. Rentzepis
Proceedings of the National Academy of Sciences Published:August 3, 2026
DOI:https://doi.org/10.1073/pnas.2615278123
Abstract
The evolutionary selection of thymine over uracil in DNA presents a paradox from a photostability perspective, since thymine is found to be more susceptible to photodamage from the intense UV radiation present on the early Earth. This study addresses this paradox by providing a comparative spectroscopic analysis of thymine and uracil under controlled 265 nm UV irradiation. To that effect, we used steady-state absorption, fluorescence, and Raman spectroscopy to quantify and compare the photochemical behavior and damage kinetics of the two nucleobases. Our results show that thymine is inherently more photoreactive than uracil, exhibiting a faster overall rate of photodamage, a broader absorption band that increases spectral overlap with the primordial UVC spectrum, and a redshifted absorption maximum located in a spectral region where solar intensity was substantially higher. However, kinetic analysis of lesion pathways reveals that thymine forms irreversible (6-4) photoproducts at a significantly lower rate than uracil, instead directing UV-induced damage primarily toward the reversible cyclobutane pyrimidine dimer pathway. These findings support the hypothesis that canonical nucleobases were evolutionarily optimized not to minimize photodamage but to localize damage within the bases and direct lesion formation toward reversible pathways amenable to nonenzymatic self-repair.
