2023-04-28 ニューサウスウェールズ大学(UNSW)
研究者は、65歳以上の人々を長期間追跡した13の国際研究の結果をまとめ、社会的なつながりと軽度認知障害(MCI)、認知症、死亡との関連を調べた。結果として、良好な社会的つながりは、MCI、認知症、死亡のリスクを下げることが示された。
研究者は、少なくとも1か月に1回は家族や友人との頻繁な交流、コミュニティ活動、良好な関係の重要性を強調し、社会的な接触を優先すべきであると勧告している。
<関連情報>
- https://newsroom.unsw.edu.au/news/health/social-interaction-reduces-dementia-risk-and-increases-longevity-study
- https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13072
13の高齢化縦断コホート研究における社会的つながりと軽度認知障害、認知症、死亡の発生リスク Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing
Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M Lipnicki, Maria Fernanda Lima-Costa, Sergio Luis Blay, Erico Castro-Costa, Xiao Shifu, Maëlenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Röhr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary Ganguli, Tiffany F. Hughes, Chung-Chou H. Chang, Michael Crowe, Tze Pin Ng, Xinyi Gwee, Denise Qian Ling Chua, Joanna Rymaszewska, Karin Wolf-Ostermann, Anna-Karin Welmer, Jean Stafford, René Mélis, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S Sachdev, Henry Brodaty, the SHARED consortium for the Cohort Studies of Memory in an International Consortium (COSMIC)
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. Published: 27 April 2023
DOI:https://doi.org/10.1002/alz.13072
Abstract
Introduction
Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers.
Methods
We used individual participant data (N = 39271, Mage = 70.67 (40-102), 58.86% female, Meducation = 8.43 years, Mfollow-up = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes.
Results
We found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
Discussion
Different aspects of social connections – structure, function, and quality – are associated with benefits for healthy aging internationally.
Highlights
- Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI.
- Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia.
- Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality.
- Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality.
- Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
