蚊の幼虫の腸をターゲットにした革新的化学戦略で致死性疾患の蔓延に対抗(Innovative chemical strategy targets mosquito larvae gut to combat spread of deadly diseases)

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2024-03-15 アリゾナ大学

蚊媒介疾患は、マラリア、デング熱、ジカウイルス、チクングニアなどの疾患で、年間数百万人を脅かす大きな課題です。アリゾナ大学の生化学者と昆虫学者は、蚊幼虫の消化管の独特なアルカリ性環境を利用して、蚊媒介疾患に対する革新的な防除戦略を開発しました。特殊な化合物を使用して、チームは蚊幼虫の腸内タンパク質を選択的に修飾し、蚊媒介疾患との戦いで重要な進展を遂げました。

<関連情報>

化学プローブで蚊の幼虫の腸の極限環境を探る Chemical Probes to Interrogate the Extreme Environment of Mosquito Larval Guts

Lindsay E. Guzmán, Anjalee N. Wijetunge, Brendan F. Riske, Brooke B. Massani, Michael A. Riehle, and John C. Jewett
Journal of the American Chemical Society  Published:March 14, 2024
DOI:https://doi.org/10.1021/jacs.3c14598

Abstract

蚊の幼虫の腸をターゲットにした革新的化学戦略で致死性疾患の蔓延に対抗(Innovative chemical strategy targets mosquito larvae gut to combat spread of deadly diseases)

Mosquito control methods are vital to curtail the spread of life-threatening illnesses, such as dengue fever, malaria, and yellow fever. Vector control technologies must be selective to minimize deleterious effects on our ecosystem. Successful methods that control mosquito larva populations utilize the uniquely high alkaline nature of the midgut. Here, we present novel protected triazabutadienes (pTBD) that are deprotected under basic conditions of the larval midgut, releasing an aryl diazonium ion (ADI) that results in protein modification. The probes contain a bioorthogonal terminal alkyne handle, enabling a selective Cu-click reaction with an azidofluorophore for quantification by SDS PAGE and visualization using fluorescence microscopy. A control TBD, unable to release an ADI, did not label the midgut. We envision our chemical probes will aid in the development of new selective mosquito control methods, thus preventing the spread of mosquito-borne illnesses with minimal impact on other organisms in the ecosystem.

有機化学・薬学
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