小型無線アンテナで細胞の通信を監視 (Tiny wireless antennas use light to monitor cellular communication)

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2024-12-20  マサチューセッツ工科大学(MIT)

MITの研究者は、微細な無線アンテナ「OCEAN」を開発し、光を用いて細胞間の電気信号を高精度でモニタリングする技術を実現しました。これにより従来のワイヤー接続不要で、液体環境内の微弱な電気変化を測定可能です。この技術は細胞のコミュニケーション理解や疾患治療の改善、薬剤評価の精度向上を可能にします。ナノスケールでの信号観測により、生物学や医学の基盤的発見への貢献が期待されています。

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有機電気散乱アンテナ 高空間分解能で電位をワイヤレスかつマルチサイトでプローブする Organic electro-scattering antenna: Wireless and multisite probing of electrical potentials with high spatial resolution

Benoit Desbiolles, Jad Hanna, Raphael Ausilio, Marta Airaghi Leccardi https://orcid.org/0000-0001-9646-5264, […], and Deblina Sarkar

Science Advances  Published:20 Dec 2024

DOI:https://doi.org/10.1126/sciadv.adr8380

小型無線アンテナで細胞の通信を監視 (Tiny wireless antennas use light to monitor cellular communication)

Abstract

Monitoring electrical potentials with high recording site density and micrometer spatial resolution in liquid is critical in biosensing. Organic electronic materials have driven remarkable advances in the field because of their unique material properties, yet limitations in spatial resolution and recording density remain. Here, we introduce organic electro-scattering antennas (OCEANs) for wireless, light-based probing of electrical signals with micrometer spatial resolution, potentially from thousands of sites. The technology relies on the unique dependence of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate light scattering properties to its doping level. Electro-optic characteristics of individual antennas varying in diameters and operating voltages were systematically characterized in saline solution. Signal-to-noise ratios up to 48 were achieved in response to 100-mV stimuli, with 2.5-mV detection limits. OCEANs demonstrated millisecond time constants and exceptional long-term stability, enabling continuous recordings over 10 hours. By offering spatial resolution of 5 μm and a recording density of 4 × 106 cm-2, OCEANs unlock new readout capabilities, potentially accelerating fundamental and clinical research.

生物工学一般
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