2025-08-22 東京大学
学習中、小脳は大脳皮質運動野へ失敗試行の直後の試行開始時に強い信号を伝達する
<関連情報>
小脳-視床-皮質経路は、雄マウスにおける学習中の運動タイミング補正のための報酬に基づく誤り後の信号を伝達する A cerebello-thalamo-cortical pathway transmits reward-based post-error signals for motor timing correction during learning in male mice
Rie Ako,Shin-Ichiro Terada & Masanori Matsuzaki
Nature Communications Published:18 August 2025
DOI:https://doi.org/10.1038/s41467-025-62831-6
Abstract
The cerebellum is critical for motor timing control and error-driven motor learning. To reveal how the cerebellum transmits these process-relevant signals to the premotor cortex, we conducted two-photon calcium imaging of cerebellar-thalamocortical axons in the premotor cortex in male mice during a self-timing lever-pull task that required 1–1.7 s of waiting after cue onset. In non-expert sessions with many lever-pulls being made before the 1-s waiting, the axons of thalamic neurons that received cerebellar outputs exhibited larger transient activity immediately after the cue onset in post-error (i.e., post-non-rewarded) trials than in post-success trials, and the waiting time and success rate were greater in post-error trials than in post-success trials. In expert sessions, the post-error-specific activity or behavior was absent. Instead, ramping activity toward lever-pull onset that did not depend on the waiting time shortened in expert sessions in comparison with non-expert sessions. Our results suggest that the cerebellum emits the reward-based post-error signal for waiting time adjustment during learning, and the well-tuned motor timing signal after learning.
