2026-02-04 北海道大学
本研究の概要
<関連情報>
- https://www.hokudai.ac.jp/news/2026/02/post-2179.html
- https://www.hokudai.ac.jp/news/pdf/260204_pr2.pdf
- https://www.cell.com/iscience/fulltext/S2589-0042(26)00211-7
- https://www.cell.com/iscience/pdf/S2589-0042(26)00211-7.pdf
マウス皮脂中のワックスエステルの詳細な組成とFAR2及びAWAT2の関与 Detailed Composition of Wax Esters in Mouse Sebum and the Involvement of FAR2 and AWAT2
Karin Kuribayashi ∙ Keisuke Jojima ∙ Moe Yamamoto ∙ Mirei Takeda ∙ Akio Kihara
iScience Published:January 28, 2026
DOI:https://doi.org/10.1016/j.isci.2026.114836
Highlights
- Mouse sebum is composed of a variety of wax esters (WEs)
- Mouse sebum contains 2α- and 2ω-type wax diesters
- Far2 and Awat2 are involved in the synthesis of specific WE species
SUMMARY
Wax esters (WEs) are lipids characteristic of sebaceous glands and are classified into wax monoesters (WmEs) and wax diesters (WdiEs). Here, we analyzed WEs in mouse sebum via liquid chromatography–tandem mass spectrometry to characterize their composition and structural diversity. We found that mouse sebum contained type 2α and type 2ω WdiEs and revealed the detailed species composition of these WdiEs together with WmEs. In knockout mice of the acyl-CoA reductase Far2, the quantities of WEs with very-long-chain fatty alcohols were reduced relative to wild type mice. In knockout mice of the acyl-CoA wax alcohol acyltransferase Awat2, the quantities of many WmEs and type 2ω WdiEs containing long-chain fatty acids were decreased. Sebum WEs were substantially more diverse than meibum WEs. These findings reveal that mouse sebum contains WEs comprising a variety of FAs and FAls and provide clues to the molecular mechanism of their production.
