2026-02-24 名古屋大学
<関連情報>
- https://www.nagoya-u.ac.jp/researchinfo/result/2026/02/post-947.html
- https://www.nagoya-u.ac.jp/researchinfo/result/upload_images/20260224_coi.pdf
- https://www.science.org/doi/10.1126/sciadv.aeb0555
腫瘍由来細胞外小胞の糸球体への輸送が尿生検の根拠となる Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy
Shota Kawaguchi, Taiga Ajiri, Rina Mitsuya, Reiko Tsuchiya, […] , and Takao Yasui
Science Advances Published:20 Feb 2026
Abstract
Urinary small extracellular vesicles (sEVs), which can reflect systemic conditions, hold great promise for noninvasive cancer diagnostics, yet the mechanism by which tumor-derived sEVs reach urine remains unclear. Here, we demonstrate that the glomerulus actively transcytoses circulating tumor-derived sEVs into urine. Using CRISPR guide RNA–tagged glioma sEVs and bioluminescent/fluorescent green-enhanced nano-lantern (GeNL)–tagged lung and pancreatic cancer sEVs, we tracked their journey from tumors to urine in multiple mouse models. In vivo and in vitro analyses revealed endocytic uptake and transcytotic release by glomerular cells, accompanied by changes in sEV size and surface composition. GeNL-tagged sEVs consistently showed higher signals in urine than plasma, indicating selective excretion. These findings redefine the glomerulus as a dynamic regulator of sEV processing and establish a mechanistic foundation for urinary liquid biopsy.
