2026-04-17 国立精神・神経医療研究センター,早稲田大学
.jpg "「脳の修復」の鍵はミエリンの“まきつき”にあり ―まきつきの評価法開発と薬剤の特定―")
図１．研究対象の”まきつき”
まきつきの促進は、脳機能の改善に貢献
＜関連情報＞
- https://www.ncnp.go.jp/topics/detail.php?@uid=B6PB89WD4PGNyDdd
- https://spj.science.org/doi/10.34133/cbsystems.0565
ミエリン増強剤スクリーニングおよび神経再生のための生体模倣マイクロファイバー Biomimetic microfibers for myelin-enhancer screening and neural regeneration
Lili Quan, Akiko Uyeda, Atsushi Sekiguchi, Ze Zhang, […] , and Rieko Muramatsu
Cyborg and Bionic Systems Published:23 Mar 2026
DOI:https://doi.org/10.34133/cbsystems.0565
Abstract
Remyelination requires the precise wrapping of axons by oligodendrocyte processes, acritical step for restoring neural circuit function. However, a lack of quantitative systemsthat recapitulate axonal geometry and chemistry has limited mechanistic andpharmacological insights into myelin wrapping. Here, we present a bioengineeredmicrofiber platform that mimics neurite architecture and surface chemistry, enabling high-content quantification of oligodendrocyte wrapping. Through compound screening, weidentified Dimemorfan, a clinically used Sigma-1 receptor agonist, as a potent enhancer ofmyelin wrapping. Dimemorfan treatment accelerated remyelination and functional recoveryin demyelinated mice and promoted myelin wrapping by human induced pluripotent stemcells (iPSC)-derived oligodendrocytes. Moreover, population-level magnetic resonanceimaging (MRI) analyses revealed increased white matter volume in Dimemorfan-administered individuals. This study establishes a biomimetic materials platform for myelinquantification and regeneration-oriented drug discovery, providing mechanistic andtranslational insights into Sigma-1 receptor-mediated control of myelin wrapping.
