2026-08-27 オックスフォード大学
＜関連情報＞
- https://www.ox.ac.uk/news/2026-08-27-new-shingles-vaccine-linked-to-lower-risk-of-coronary-heart-disease-stroke-and
- https://www.nature.com/articles/s41591-026-04606-0
組換え型帯状疱疹ワクチンと心血管イベントのリスク Recombinant shingles vaccination and the risk of cardiovascular events
Fabiana Corsi-Zuelli,,Fang Li,Rachel Upthegrove,John A. Todd,Betty Raman,Paul J. Harrison & Maxime Taquet
Nature Medicine Published:26 August 2026
DOI:https://doi.org/10.1038/s41591-026-04606-0
Fig. 1: Association between recombinant shingles vaccine and risk of cardiovascular outcomes within 7 years of vaccination.
Abstract
The recombinant herpes zoster (shingles) vaccine may reduce risks of cardiovascular disease. However, existing studies have compared vaccine recipients with non-recipients and, thus, are susceptible to confounding. To mitigate these biases, we conducted a natural experiment created by the rapid transition from the live attenuated to the recombinant shingles vaccine in the United States. We compared incidences of a composite cardiovascular endpoint (ischemic heart disease, heart failure or ischemic stroke) among adults aged ≥60 years vaccinated immediately before versus immediately after this transition. The recombinant vaccine was associated with a 9% decrease in cardiovascular burden over 7 years (restricted mean time lost (RMTL) ratio = 0.91, 95% confidence interval (CI): 0.88−0.95). The association attenuated over time and was significant for ischemic heart disease (10% decrease in burden; RMTL ratio = 0.90, 95% CI: 0.87−0.94) and heart failure (12% decrease in burden; RMTL ratio = 0.88, 95% CI: 0.83−0.93) in both sexes and ischemic stroke in males (12% decrease; RMTL ratio = 0.88, 95% CI: 0.78−0.98). An association was also seen for atrial fibrillation (7% decrease in burden; RMTL = 0.93, 95% CI: 0.88−0.98) but not other cardiac, peripheral and cerebrovascular outcomes. Results were consistent in secondary analyses. These results justify clinical trials and mechanistic studies to investigate potential cardioprotective effects of shingles vaccines.
