2023-08-25 カロリンスカ研究所(KI)
◆その結果、無重力状態でT細胞の遺伝子発現に重要な変化が見られ、細胞は未熟な状態になりました。しかし、21日後にはほぼ正常に戻りましたが、実験終了後7日間の解析では、一部の変化が再び見られました。これらの研究結果は、宇宙飛行士の免疫システムが宇宙環境にどのように影響を受けるかを理解し、適切な対策を開発するための重要なステップです。将来の宇宙ミッションでの宇宙飛行士の健康を保護するための研究です。
<関連情報>
- https://news.ki.se/how-being-in-space-impairs-astronauts-immune-system
- https://www.science.org/doi/10.1126/sciadv.adg1610
ボランティアを21日間、乾燥浸漬ベッドで微小重力にさらすと、遺伝子発現が変化し、T細胞が適応する。 Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells
Carlos J. Gallardo-Dodd,Christian Oertlin,Julien Record,Rômulo G. Galvani,Christian Sommerauer,Nikolai V. Kuznetsov,Evangelos Doukoumopoulos,Liaqat Ali,Mariana M. S. Oliveira,Christina Seitz,Mathias Percipalle,Tijana Nikić,Anastasia A. Sadova,Sofia M. Shulgina,Vjacheslav A. Shmarov,Olga V. Kutko,Daria D. Vlasova,Kseniya D. Orlova ,Marina P. Rykova ,John Andersson ,Piergiorgio Percipalle ,Claudia Kutter,Sergey A. Ponomarev, and Lisa S. Westerberg
Science Advances Published:25 Aug 2023
DOI:https://doi.org/10.1126/sciadv.adg1610
Abstract
The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14, and 21 during DI, and 7 days after DI. RNA sequencing of CD3+ T cells revealed transcriptional alterations across all time points, with most changes occurring 14 days after DI exposure. At day 21, T cells showed evidence of adaptation with a transcriptional profile resembling that of 7 days before DI. At 7 days after DI, T cells again changed their transcriptional profile. These data suggest that T cells adapt by rewiring their transcriptomes in response to simulated weightlessness and that remodeling cues persist when reexposed to normal gravity.
