新鮮な空気を吸うことで、薬物産生細胞はより長く生き続ける(A breath of fresh air keeps drug-producing cells alive longer)

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2023-11-09 ノースウェスタン大学

◆ノースウェスタン大学主導の研究チームがDARPA契約を受け、体内の睡眠・覚醒サイクルを制御するための埋め込み式「生きた薬局」を開発する取り組みを進めています。
◆最新の研究では、特製の装置が現場で酸素を生成し、これにより生体内の細胞を長期間生かすことが可能になりました。続く実験では、新しいデバイス(ecO2)が、低酸素環境下で人工的に培養された細胞の約70〜80%をほぼ1か月間、生存させたとされ、これは有望な結果です。

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移植細胞を用いた治療のための電極触媒によるオンサイト酸素化 Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

Inkyu Lee,Abhijith Surendran,Samantha Fleury,Ian Gimino,Alexander Curtiss,Cody Fell,Daniel J. Shiwarski,Omar Refy,Blaine Rothrock,Seonghan Jo,Tim Schwartzkopff,Abijeet Singh Mehta,Yingqiao Wang,Adam Sipe,Sharon John,Xudong Ji,Georgios Nikiforidis,Adam W. Feinberg,Josiah Hester,Douglas J. Weber,Omid Veiseh,Jonathan Rivnay & Tzahi Cohen-Karni
Nature Communications  Published:09 November 2023
DOI:https://doi.org/10.1038/s41467-023-42697-2

新鮮な空気を吸うことで、薬物産生細胞はより長く生き続ける(A breath of fresh air keeps drug-producing cells alive longer)

Abstract

Implantable cell therapies and tissue transplants require sufficient oxygen supply to function and are limited by a delay or lack of vascularization from the transplant host. Previous exogenous oxygenation strategies have been bulky and had limited oxygen production or regulation. Here, we show an electrocatalytic approach that enables bioelectronic control of oxygen generation in complex cellular environments to sustain engineered cell viability and therapy under hypoxic stress and at high cell densities. We find that nanostructured sputtered iridium oxide serves as an ideal catalyst for oxygen evolution reaction at neutral pH. We demonstrate that this approach exhibits a lower oxygenation onset and selective oxygen production without evolution of toxic byproducts. We show that this electrocatalytic on site oxygenator can sustain high cell loadings (>60k cells/mm3) in hypoxic conditions in vitro and in vivo. Our results showcase that exogenous oxygen production devices can be readily integrated into bioelectronic platforms, enabling high cell loadings in smaller devices with broad applicability.

医療・健康
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