2024-04-25 カロリンスカ研究所(KI)
<関連情報>
- https://news.ki.se/advanced-cell-atlas-opens-new-doors-in-biomedical-research
- https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03246-2
シングルセルアトラス:シングルセル・マルチオミクス・ヒト細胞百科事典 Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
Lu Pan,Paolo Parini,Roman Tremmel,Joseph Loscalzo,Volker M. Lauschke,Bradley A. Maron,Paola Paci,Ingemar Ernberg,Nguan Soon Tan,Zehuan Liao,Weiyao Yin,Sundararaman Rengarajan,Xuexin Li,on behalf of The SCA Consortium
Genome Biology Published:19 April 2024
DOI:https://doi.org/10.1186/s13059-024-03246-2
Abstract
Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues. We construct its complement web-based platform, the Single Cell Atlas (SCA, www.singlecellatlas.org), to enable vast interactive data exploration of deep multi-omics signatures across human fetal and adult tissues. The atlas resources and database queries aspire to serve as a one-stop, comprehensive, and time-effective resource for various omics studies.
