2025-06-18 カリフォルニア大学ロサンゼルス校 (UCLA)
<関連情報>
- https://newsroom.ucla.edu/stories/new-computational-tool-helps-detect-hidden-genetic-mutations-linked-to-cancer-and-other-diseases
- https://www.nature.com/articles/s41587-025-02701-0
moPepGenによる非共有ペプチドの同定 Identification of non-canonical peptides with moPepGen
Chenghao Zhu,Lydia Y. Liu,Annie Ha,Takafumi N. Yamaguchi,Helen Zhu,Rupert Hugh-White,Julie Livingstone,Yash Patel,Thomas Kislinger & Paul C. Boutros
Nature Biotechnology Published:16 June 2025
DOIhttps://doi.org/10.1038/s41587-025-02701-0
Abstract
Proteogenomics is limited by the challenge of modeling the complexities of gene expression. We create moPepGen, a graph-based algorithm that comprehensively generates non-canonical peptides in linear time. moPepGen works with multiple technologies, in multiple species and on all types of genetic and transcriptomic data. In human cancer proteomes, it enumerates previously unobservable noncanonical peptides arising from germline and somatic genomic variants, noncoding open reading frames, RNA fusions and RNA circularization.
