2026-04-24 カリフォルニア大学リバーサイド校（UCR）
＜関連情報＞
- https://news.ucr.edu/articles/2026/04/24/immune-surveillance-structures-found-skin-hair-follicles
- https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1721181/full
マウスの皮膚免疫監視機構が毛包上皮に局在していることを示す証拠 Evidence for murine cutaneous immune surveillance localized to hair follicle epithelium
Diana Del Castillo,Hannah Kim,Sumaya Troy Alaama,David D. Lo
Frontiers in Cell and Developmental Biology Published:24 April 2026
DOI:https://doi.org/10.3389/fcell.2026.1721181
Abstract
Epithelial expression of the gene encoding the anti-microbial peptide PGRP-S was previously found to be specifically associated with M cells in mucosal epithelium. However, recent studies have found PGRP-S expression by a variety of epithelia not providing direct M cell-like microparticle transcytosis into lymphoid tissues. Thus, in mouse epidermis we found that PGRP-S expression, revealed by a dsRed reporter, was specific to subsets of hair follicle epithelium, depending on the specific skin region, and not associated with lymphoid aggregates. Interestingly, expression in flank skin hair follicle epithelium was also transiently inducible upon exposure to a suspension of Staphylococcus aureus. Altogether, the topology of hair follicles and location of dsRed-expressing epithelia are consistent with a model in which this PGRP-S-dsRed reporter identifies a population in hair follicles associated with surveillance of environmental exposures.
