2026-06-04 合肥物質科学研究院（HFIPS）
◆この構造により触媒活性部位が増加し、金属間相互作用が強化され、天然酵素を大幅に上回る触媒活性を実現した。開発されたナノザイムを利用して、コレステロール、尿酸、グルコースを検出する比色センサーを構築し、スポンジ型ウェアラブルデバイスへ組み込んだところ、汗を採取して10分以内に分析できることを実証した。さらにスマートフォン画像解析とAI技術を組み合わせることで、運動中に複数の生体指標を同時監視できる腕時計型システムへ発展させた。
◆本技術は採血を必要としない非侵襲的な健康モニタリングを可能にし、精密医療、ウェアラブルバイオセンサー、疾病管理などへの応用が期待される。研究は高性能ナノザイム設計の新たな指針を示す成果である。
Structural design of the enzyme-nanoenzyme cascade system and its practical applications. (Image by LIN Dan)
＜関連情報＞
- https://english.hf.cas.cn/nr/rn/202606/t20260604_1161125.html
- https://www.sciencedirect.com/science/article/abs/pii/S0956566326004586
カスケード増幅型2次元超薄型六角形CuドープLDOナノザイムを用いた、汗代謝物の多重ウェアラブルモニタリング Cascade-amplified 2D ultrathin hexagonal Cu-doped LDO nanozyme for multiplexed wearable monitoring of sweat metabolites
Ruoxuan Jiang, Anqi Liu, Qipeng Zhang, Lei Pan, Shudong Zhang, Dan Lin, Liang Yang, Changlong Jiang
Biosensors and Bioelectronics Available online: 20 May 2026
DOI:https://doi.org/10.1016/j.bios.2026.118826
Abstract
Sweat-based metabolic monitoring offers a non-invasive alternative to blood tests, but its clinical utility is limited by the limited catalytic efficiency of current nanozyme sensors. Bimetallic nanozymes, with their intermetallic synergy, hold promise to overcome this limitation, yet rational design strategies remain underexplored. Herein, we report a Cu-doped Co-Al layered double oxide (Co2AlCu0.7 LDO) with an ultrathin hexagonal nanosheet morphology that exhibits exceptional peroxidase-like activity (Km = 0.30 mM, Vmax = 2.932 × 10−6 M s−1). Mechanistic studies reveal that the intrinsic Co-Al bimetallic framework provides a synergistic electronic basis, while Cu doping optimizes the d-band center of metal active sites and introduces abundant oxygen vacancies, which act as synergistic active centers to facilitate H2O2 activation and dramatically enhance peroxidase-like activity. By immobilizing biomarker-specific oxidases onto the LDO nanosheets, we constructed an enzyme-nanozyme cascade reactor for sensitive detection of cholesterol, uric acid, and glucose. For point-of-care translation, this reactor was integrated into a colorimetric sponge coupled with smartphone imaging and machine learning, yielding a portable platform and a conceptual wristwatch for non-invasive sweat analysis. This work not only provides novel design strategies for high-performance bimetallic nanozymes but also expands its potential as advanced functional biomaterials for next-generation biosensing platforms of clinical diagnostics and therapeutic monitor.
