2026-07-13 ペンシルベニア州立大学（PennState）
＜関連情報＞
- https://www.psu.edu/news/health-and-human-development/story/eating-avocado-day-lowers-heart-disease-risk-factor-people
- https://www.lipidjournal.com/article/S1933-2874(26)00397-1/fulltext
腹部肥満の成人における、1日1個のアボカド摂取が、通常の摂取量と比較してリポタンパク質粒子濃度に及ぼす影響：ランダム化比較試験である「習慣的食事とアボカド試験」の副次的研究 Effect of incorporating 1 avocado per day on lipoprotein particle concentrations compared to habitual intake in adults with abdominal obesity: An ancillary study of the Habitual Diet and Avocado Trial, a randomized controlled trial
Janhavi J. Damani, PhD ∙ Penny M. Kris-Etherton, PhD ∙ Nirupa R. Matthan, PhD ∙ … ∙ Joan Sabaté, MD, DrPH ∙ David M. Reboussin, PhD ∙ Kristina S. Petersen, PhD
Journal of Clinical Lipidology Published:June 12, 2026
DOI:https://doi.org/10.1016/j.jacl.2026.06.005
Highlights
- In US adults with abdominal obesity, intake of 1 avocado/day for 26 weeks reduced low-density lipoprotein particles.
- No changes were observed for apolipoprotein B or A‑1, or triglyceride‑rich, or high‑density lipoprotein particles and their subclasses.
- Incorporating avocados into habitual diets may be a feasible dietary strategy to lower fasting LDL-P.
- The LDL-P lowering observed with avocado intake corresponds to an approximate 4% lower risk of cardiovascular disease.
Abstract
BACKGROUND
Avocado intake improves blood lipid profiles, but the effect on lipoprotein particles and subclasses is less clear.
OBJECTIVE
The aim was to investigate the effect of consuming 1 avocado per day for 26 weeks on the change in lipoprotein particles and subclasses compared to a habitual diet without supplemental avocados in free-living adults with abdominal obesity.
METHODS
This is an ancillary study of the Habitual Diet and Avocado Trial, a multicenter, parallel-arm, 26-week randomized controlled trial. The Avocado-supplemented Diet Group was provided with 1 avocado per day, and the Habitual Diet Group was instructed to follow their habitual diet. Fasting plasma samples collected at baseline and 26 weeks were analyzed for concentrations of lipoprotein particles and subclasses (exploratory outcomes) using nuclear magnetic resonance spectroscopy. Between-group differences in the 26-week change from baseline were evaluated using linear regression, with adjustment for study site.
RESULTS
The analytical sample included 786 participants (74% female; aged 51 ± 14 years; body mass index 32.9 ± 5.4 kg/m2) with available data (Avocado-supplemented Diet Group: n = 389; Habitual Diet Group: n = 397). The Avocado-supplemented Diet Group had a reduction in total low-density lipoprotein (LDL) particle concentration (mean difference: −49.1 nmol/L; 95% CI: −83.6, −14.5; P = .005) compared to the Habitual Diet Group. No between-group differences were observed for LDL particle size and subclasses, triglyceride-rich lipoprotein particles, high-density lipoprotein particles, or apolipoproteins A or B.
CONCLUSION
Incorporating 1 avocado per day into habitual diets for 26 weeks reduced the concentration of atherogenic LDL particles without affecting other lipoprotein particles and subclasses in adults with abdominal obesity.
