2026-08-27 中国科学院（CAS）
Key factors affecting dsRNA/siRNA design efficacy. (Image by XIEG)
＜関連情報＞
- https://english.cas.cn/newsroom/research-news/202608/t20260827_1189377.shtml
- https://www.nature.com/articles/s42003-026-10663-5
合理的なdsRNA設計、スケーラブルな生産、およびナノデリバリーによるスプレー誘導型遺伝子サイレンシングの強化 Rational dsRNA design, scalable production and nanodelivery to enhance spray-induced gene silencing
Guoning Zhu,Chao Xu & Tao Zhang
Communications Biology Published:14 July 2026
DOI:https://doi.org/10.1038/s42003-026-10663-5
Abstract
Spray-induced gene silencing (SIGS) provides a sustainable, highly targeted alternative to chemical pesticides. This review summarizes recent advances in dsRNA technology through a design-to-delivery framework. Key focuses include bioinformatics-driven multi-target dsRNA design for improved stability and efficacy, cost-effective microbial and cell-free synthesis platforms for scalable production, and nanocarriers that protect dsRNA from degradation while enhancing delivery. Integrating rational design, efficient production, and precision nanodelivery will accelerate SIGS from laboratory concept to practical, eco-friendly tool for global crop protection and sustainable agriculture.
