2022-12-09 バッファロー大学(UB)
Novel hydrogel scaffolds developed by the UB researchers containing various concentrations of strontium. Photo: Michelle Visser.
歯科インプラントの成功は、インプラント表面への軟組織の成長と接着に依存している。UB研究者らによる以前の研究では、骨密度と強度を向上させる骨探索元素であるストロンチウムが、軟組織の機能もサポートすることが判明している。ストロンチウムは、結合組織を形成し、創傷治癒に重要な役割を果たす細胞の一種である線維芽細胞の機能を促進することができることを発見したのである。
今年初めにJournal of Biomedical Materials Research誌に発表されたこの新しい研究では、低濃度でもストロンチウムを充填した足場材が、歯肉線維芽細胞の活性を刺激して創傷治癒を促進することが明らかにされました。
<関連情報>
- https://www.buffalo.edu/news/releases/2022/12/007.html
- https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.37439
歯肉線維芽細胞機能を促進するストロンチウム含有ヒドロゲル足場材 Strontium-loaded hydrogel scaffolds to promote gingival fibroblast function
Shahad Bakheet Alsharif,Rofida Wali,Stephen T. Vanyo,Sebastiano Andreana,Kaiwen Chen,Bhoomika Sheth,Mark T. Swihart,Rosemary Dziak,Michelle B. Visser
Journal of Biomedical Materials Research Published: 29 August 2022
DOI:https://doi.org/10.1002/jbm.a.37439
Abstract
Dental implant clinical success is dependent on effective peri-implant tissue attachment to the trans-mucosal portion following placement. Modification of transmucosal implant surfaces can improve cellular adhesion and function leading to formation of an effective soft-tissue seal during healing, of which gingival fibroblasts are prominent cells to migrate to repair wounds and crucial for the development of a collagen rich connective tissue. Biocompatible loaded scaffold materials have been developed to allow local release of molecules with effective biological activity. Our previous studies indicate that strontium can promote gingival fibroblast metabolism, decrease apoptosis and support adhesion to titanium healing abutments. In this study, we developed a strontium-loaded alginate hydrogel scaffold which can be easily personalized to fit over any size and shape of implant transmucosal collar or healing abutment. Results indicate that biologically active strontium ions are effectively released from loaded alginate hydrogel material to promote fibroblast viability and migration to repair in vitro wounds similar to that of strontium citrate solution. Overall, this novel strontium-loaded alginate scaffold device displays good biocompatibility and functionality, demonstrating high potential as a system to provide local delivery of strontium to improve peri-implant m
