2026-05-13 北里大学
本研究の概念図
＜関連情報＞
- https://www.kitasato-u.ac.jp/jp/news/20260513-03.html
- https://www.nature.com/articles/s41564-026-02350-2
アカルボースは、マウスにおけるアナフィラキシーを抑制するために、腸内細菌叢による食事性炭水化物の利用を方向転換させる Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice
Kyosuke Yakabe,Yukinobu Inoue,Yuki Yanagisawa,Shungo Imai,Shunnosuke Suwa,Masahiro Ando,Yuqing Wu,Rina Kurokawa,Srirat Tanakorn,Takeshi Haneda,Tsuyoshi Miki,Masahiro Ito,Akiyoshi Hirayama,Yosuke Kurashima,Shinji Fukuda,Koji Hase,Wataru Suda,Haruko Takeyama,Satoko Hori & Yun-Gi Kim
Nature Microbiology Published:12 May 2026
DOI:https://doi.org/10.1038/s41564-026-02350-2
Abstract
Microbiota-accessible carbohydrates modulate host immunity by shaping gut microbial composition and metabolism. However, their role in modulating the microbiota to influence allergic responses is unclear. Here we show that a widely used antidiabetic agent, the α-glucosidase inhibitor acarbose, redirects dietary carbohydrate utilization by gut bacteria to suppress mast-cell-dependent anaphylaxis in mice, independently of adaptive immune responses. Enhanced carbohydrate availability promoted the proliferation of Parabacteroides distasonis in the mouse gut, leading to increased succinate abundance and intracellular NAD+ levels, and reduced reliance on b-type cytochrome-dependent anaerobic respiration. Direct administration of succinate suppressed systemic anaphylaxis and mast cell degranulation in vitro, implicating succinate as a key effector. A human cohort analysis revealed that patients treated with α-glucosidase inhibitors showed a lower incidence of anaphylaxis than untreated individuals. These findings uncover a previously unrecognized gut-microbiota-mediated pathway linking dietary carbohydrate metabolism to systemic immune regulation.
