2026-09-25 ペンシルベニア州立大学（Penn State）
＜関連情報＞
- https://www.psu.edu/news/research/story/how-quickly-people-age-during-midlife-predicted-memory-lapses-10-years-later
- https://academic.oup.com/biomedgerontology/article-abstract/81/10/glag202/8762939?redirectedFrom=fulltext
- https://medibio.tiisys.com/181634/
- https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz70856_105687
エピジェネティックな年齢加速と自己申告による日常的な記憶障害との関連性：全国日常生活体験調査からの証拠 Linking epigenetic age acceleration to self-reported daily memory lapses: evidence from the National Study of Daily Experiences
Heejung Jang, PhD, Jennie C Holmberg, MS, Jody S Nicholson, PhD, Faith R Shannon, Eric S Cerino, PhD, Hye Won Chai, PhD, Susan T Charles, PhD, David M Almeida, PhD
The Journals of Gerontology: Series A Published:17 August 2026
DOI:https://doi.org/10.1093/gerona/glag202
Abstract
DNA methylation algorithms, such as DunedinPACE, are increasingly used to study the mechanisms of aging and to identify associations with risk factors in adult development and aging. Growing evidence suggests that an increased pace of epigenetic aging is associated with cognitive impairment and dementia, but the correlation between epigenetic aging and subjective cognitive complaints (eg, forgetting a name or forgetting to take your medication), an early marker of dementia risk, remains unexplored. Using data from The National Study of Daily Experiences (NSDE) and Midlife in the United States (MIDUS; N = 232), we examined the relationship between epigenetic aging rate (ie, DunedinPACE) and self-reported daily memory lapses (ie, occurrence, irritation, interference) in midlife and older adults. We found no significant main effects of the rate of epigenetic aging on self-reported memory lapses; however, a significant chronological age interaction indicates that among the comparatively younger adults in the sample (age 40-49), faster than average rates of aging (ie, higher DunedinPACE) were associated with more prospective memory lapses approximately a decade later as well as greater reports of prospective memory lapse irritation and interference. Additionally, for respondents in their forties, a higher DunedinPACE was associated with both greater prospective memory lapse irritation and interference. These results suggest that early midlife may be a sensitive period during which the rate of epigenetic aging is more influential on cognitive health outcomes.
展望記憶と認知症リスク：血液ベースの神経変性バイオマーカーとの関連性の検討 Prospective memory and dementia risk: Examining associations with blood-based neurodegenerative biomarkers
Erin E. Harrington, Jennifer E. Graham-Engeland, Jacqueline A. Mogle, Mindy J. Katz, Richard B. Lipton, Martin J. Sliwinski, Orfeu M. Buxton, Conner K Ryan …
Alzheimer’s & Dementia Published: 07 January 2026
DOI:https://doi.org/10.1002/alz70856_105687
Abstract
Background
Prospective memory (PM; i.e., memory for future actions or events) lapses, such as forgetting to attend an appointment or take medication on time, may be one of the earliest indicators of mild cognitive impairment (MCI) and Alzheimer’s Disease and related dementias (ADRD). Yet, limited work has examined links between PM and biomarkers of ADRD such as neurodegenerative biomarkers. Determining such associations may be crucial in early identification of MCI and ADRD risk. The present work addressed this gap by examining self-reported PM lapses and blood-based levels of β-amyloid and tau biomarkers among older adults.
Method
Older adults (N = 275, Mage=77.02, 68% female, non-Hispanic White) enrolled in the Einstein Aging Study completed a two-week protocol, that included blood draws for biomarker assays of β-amyloid (Aβ40, Aβ42, Aβ42:Aβ40) and phosphorylated tau (pTau181). Participants reported PM lapses at the end of each day of the two-week period via study-provided smartphones. Independent regression analyses examined links between neurodegenerative biomarkers and PM lapses (daily reports averaged across the two weeks) within the full sample and stratified by gender. Covariates included age and educational attainment.
Result
Higher levels of pTau181 were associated with reporting more PM lapses on average across the two weeks (b = 0.01, p = .005). When examined within gender, this effect appeared to be driven by women: higher levels of pTau181 were associated with reporting more PM lapses among women (n = 186, b = 0.02, p < .001) but not men (n = 89, b = 0.00, p = .678). No significant relationships emerged with β-amyloid (ps>.123).
Conclusion
The present findings indicate that in older adults, PM lapses are related to elevated levels of pTau181 in women by not men. This finding is noteworthy, as markers of pTau181 are detectable in blood in preclinical Alzheimer’s disease and increases correlate with risk of disease progression. As such, women experiencing more frequent PM forgetting and elevated levels of pTau181 may be at risk for future pathology. However, longitudinal research is needed to determine whether this relationship persists across time and its association with objective cognitive decline. Continued research in this area may inform early risk detection for MCI and ADRD.
