孫の死産リスクは祖母の体重と関連する(Grandchild’s stillbirth risk linked to grandma’s weight)

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2023-12-05 ミシガン大学

Close-up of stethoscope and ultrasound scan on wooden background. Image credit: dimarik, iStock

◆米ミシガン大学の研究により、BMIが30以上の妊娠中の女性は通常BMIの女性に比べて死産のリスクが高まることが示され、新たな研究では祖母のBMIも孫の死産リスクに影響することが明らかになった。
◆BMIが25-29.9の祖母は、孫の死産リスクが41%高くなり、BMIが30以上の場合は62%高まった。研究者は、このリスクの多くが祖母に直接関連しており、女性胎児の卵子の遺伝子発現に影響を与える可能性があると指摘。肥満による炎症が胎児の生殖細胞にエピジェネティックな変化をもたらす可能性があるとし、肥満が世代を通じて影響を及ぼすことが深刻であると強調しています。

<関連情報>

妊娠初期の母親の肥満度と孫の死産リスク: 全国3世代コホート研究 Grandmaternal body mass index in early pregnancy and risk of grandoffspring stillbirth: A nationwide, three-generation cohort study

Eduardo Villamor, Sven Cnattingius
American Journal of Epidemiology  Published:05 December 2023
DOI:https://doi.org/10.1093/aje/kwad235

Abstract

We investigated the association between maternal grandmaternal early pregnancy body mass index (BMI) and grandoffspring stillbirth risk in a Swedish population-based three-generation cohort of 176,908 grandmothers (F0), 197,579 mothers (F1), and 316,459 grandoffspring (F2) born 1997-2016. There were 998 stillbirths (risk, 3.2 per 1000 births). Compared with grandmaternal BMI 18.5-24.9, adjusted relative risks [RR (95% CI)] of grandoffspring stillbirth for BMI 25.0-29.9 and ≥30 were, respectively, 1.41 (1.15, 1.72) and 1.62 (1.14, 2.30). RR (95% CI) for corresponding maternal (F1) BMI categories were, respectively, 1.32 (1.06, 1.65) and 1.77 (1.39, 2.25). Maternal BMI mediated only 19% of this relation. Grandmaternal preeclampsia and maternal small-for-gestational age (SGA) birth were related to increased F2 stillbirth risk but did not mediate the association between grandmaternal BMI and grandoffspring stillbirth risk. To explore whether this association was explained by factors shared within families, we studied the relation of maternal full sisters’ BMI and stillbirth risk in 101,368 pregnancies. Stillbirth RR (95% CI) for full sisters’ BMI 25.0-29.9 and ≥30 compared with 18.5-24.9 were, respectively, 0.76 (0.51, 1.13) and 0.88 (0.55, 1.40). In conclusion, grandmaternal overweight and obesity are associated with grandoffspring stillbirth. This association is not fully explained by shared familial factors.

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