2026-10-15 テキサス大学オースティン校（UT Austin）
＜関連情報＞
- https://news.utexas.edu/2026/10/15/the-brains-tug-of-war-between-impulse-and-self-control/
- https://www.cell.com/neuron/fulltext/S0896-6273(26)00726-9
自動行動の中断時の眼窩前頭皮質の価値ダイナミクスと線条体集団の幾何学的構造 Orbitofrontal value dynamics and striatal population geometry during interruption of automatic behavior
Thomas W. Elston ∙ Joni D. Wallis
Neuron Published:October 9, 2026
DOI:https://doi.org/10.1016/j.neuron.2026.09.016
Highlights
- OFC transmits state-dependent values to striatal circuits
- Distinct neural dynamics in OFC and CdN during inhibition of automatic responses
- Disrupted CdN population geometry but not firing rates during response inhibition
- OFC→CdN LFP synchronization associated with overriding automatic responses
Summary
A core feature of cognitive control is the ability to interrupt behaviors that conflict with current goals. Disorders impairing this ability involve abnormal interactions between the orbitofrontal cortex (OFC) and the caudate nucleus (CdN). However, how these regions normally interact to interrupt automatic behaviors remains unknown. To find out, we trained monkeys on a decision task that created a conflict between competing value representations, thus evoking an automatic-then-controlled response pattern that provided a window into how initial responses are interrupted and overridden. Simultaneous OFC-CdN Neuropixels recordings revealed that during corrective responses, OFC population dynamics vacillated between competing value states. These dynamics appeared to be transmitted to the CdN via enhanced local field potential synchronization, which coincided with disruption of structured CdN population activity. Critically, this occurred without changes in striatal firing rate. This suggests that interrupting an automatic response can occur through top-down disruption of striatal population geometry without suppressing firing rates.
