2023-04-19 マサチューセッツ工科大学(MIT)
このデバイスは、テープなしで皮膚に接着するシリコーンベースのポリマーであるPDMSで作られています。ブタの皮膚を使ったテストでは、皮膚を透過する薬剤の量が、超音波の補助なしに皮膚を通過できる量の26倍であることがわかりました。このデバイスは、全身的な毒性が少なく、より局所的で快適なコントロールが可能であることが期待されています。
<関連情報>
- https://news.mit.edu/2023/wearable-patch-can-painlessly-deliver-drugs-through-skin-0419
- https://onlinelibrary.wiley.com/doi/10.1002/adma.202300066
キャビテーションで強化された化粧品デリバリーのためのコンフォーマブル超音波パッチ A Conformable Ultrasound Patch for Cavitation-Enhanced Transdermal Cosmeceutical Delivery
Chia-Chen Yu, Aastha Shah, Nikta Amiri, Colin Marcus, Md Osman Goni Nayeem, Amit Kumar Bhayadia, Amin Karami, Canan Dagdeviren
Advanced Materials Published: 19 March 2023
DOI:https://doi.org/10.1002/adma.202300066
Abstract
Increased consumer interest in healthy-looking skin demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. Here, a conformable ultrasound patch (cUSP) that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis in the fluid coupling medium between the patch and the skin is reported. The cUSP consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets (0.8 cm2, 1 mm deep) over larger areas of conformal contact (20 cm2). Multiphysics simulation models, acoustic spectrum analysis, and high-speed videography are used to characterize transducer deflection, acoustic pressure fields, and resulting cavitation bubble dynamics in the coupling medium. The final system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro with a 10 min ultrasound application, demonstrating the suitability of the device for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.
