新しいテストにより、薬局の棚に芋え隠れする既存の抗生物質が、スヌパヌバグを治療できるこずが明らかになりたした。(New test reveals existing antibiotics, hiding in plain sight on pharmacy shelves, can cure superbugs)

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2023-04-27 カリフォルニア倧孊サンタバヌバラ校(UCSB)

米囜カリフォルニア倧孊サンタバヌバラ校の研究者たちは、FDA認可の抗生物質がスヌパヌバグを効果的に治療できるこずを瀺す新しい怜査方法を開発したした。しかし、既存の暙準的な怜査方法では効果がないず予枬されおいるため、これらの抗生物質は凊方されおいたせん。
新しい怜査方法は、抗生物質の開発、怜査、凊方方法を改善する可胜性がありたす。この研究は、珟圚利甚可胜な抗生物質の凊方ず䜿甚を最適化し、新しい抗生物質を発芋する取り組みを匷化するこずで、现菌耐性の戊いに重芁な意矩がありたす。

<関連情報>

抗菌薬耐性評䟡のための蚺断粟床を高めたFDA認可の抗生物質の再評䟡 Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance

Douglas M. Heithoff,Lucien Barnes V,Scott P. Mahan,Jeffrey C. Fried,Lynn N. Fitzgibbons,John K. House,Michael J. Mahan
Cell Reports Medicine  Published:April 27, 2023
DOI:https://doi.org/10.1016/j.xcrm.2023.101023

新しいテストにより、薬局の棚に芋え隠れする既存の抗生物質が、スヌパヌバグを治療できるこずが明らかになりたした。(New test reveals existing antibiotics, hiding in plain sight on pharmacy shelves, can cure superbugs)

Highlights

•Antibiotic testing in cell culture medium improves prediction of clinical outcome
•Antibiotics rejected by standard testing cure drug-resistant infections
•Ineffective antibiotics are identified despite indicated use by standard testing

Summary

Accurate assessment of antibiotic susceptibility is critical for treatment of antimicrobial resistant (AMR) infections. Here, we examine whether antimicrobial susceptibility testing in media more physiologically representative of in vivo conditions improves prediction of clinical outcome relative to standard bacteriologic medium. This analysis reveals that ∌15% of minimum inhibitory concentration (MIC) values obtained in physiologic media predicted a change in susceptibility that crossed a clinical breakpoint used to categorize patient isolates as susceptible or resistant. The activities of antibiotics having discrepant results in different media were evaluated in murine sepsis models. Testing in cell culture medium improves the accuracy by which MIC assays predict in vivo efficacy. This analysis identifies several antibiotics for treatment of AMR infections that standard testing failed to identify and those that are ineffective despite indicated use by standard testing. Methods with increased diagnostic accuracy mitigate the AMR crisis via utilizing existing agents and optimizing drug discovery.

 

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