消防士における前立腺がん関連遺伝子の制御の変化を示す研究結果(Research shows altered regulation of genes linked to prostate cancer among firefighters)

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2024-05-13 アリゾナ大学

アリゾナ大学とミシガン大学の研究によると、消防士は仕事中の化学物質暴露により前立腺がんのリスクが高まる可能性があります。消防活動中の煙や消火泡への暴露が、前立腺がんの発生率を一般人口の1.21倍にする要因と考えられています。研究では、経験豊富な消防士と新人消防士の間で、前立腺がんリスクと関連する遺伝子の領域で異なるエピジェネティック修飾が見られました。この修飾は特定の化学物質、特に消火泡に使用されるPFASによって引き起こされる可能性があります。

<関連情報>

消火活動、ペルフルオロアルキル物質およびポリフルオロアルキル物質と前立腺がんリスクに関連する遺伝子のDNAメチル化 Firefighting, per- and polyfluoroalkyl substances, and DNA methylation of genes associated with prostate cancer risk

Margaret Quaid, Jaclyn M. Goodrich, Miriam M. Calkins, Judith M. Graber, Derek Urwin, Jamie Gabriel, Alberto J. Caban-Martinez, Rebekah L. Petroff, Casey Grant, Shawn C. Beitel, Sally Littau … Environmental and Molecular Mutagenesis  Published: 24 March 2024
DOI:https://doi.org/10.1002/em.22589

消防士における前立腺がん関連遺伝子の制御の変化を示す研究結果(Research shows altered regulation of genes linked to prostate cancer among firefighters)

Abstract

Prostate cancer is the leading incident cancer among men in the United States. Firefighters are diagnosed with this disease at a rate 1.21 times higher than the average population. This increased risk may result from occupational exposures to many toxicants, including per- and polyfluoroalkyl substances (PFAS). This study assessed the association between firefighting as an occupation in general or PFAS serum levels, with DNA methylation. Only genomic regions previously linked to prostate cancer risk were selected for analysis: GSTP1, Alu repetitive elements, and the 8q24 chromosomal region. There were 444 male firefighters included in this study, with some analyses being conducted on fewer participants due to missingness. Statistical models were used to test associations between exposures and DNA methylation at CpG sites in the selected genomic regions. Exposure variables included proxies of cumulative firefighting exposures (incumbent versus academy status and years of firefighting experience) and biomarkers of PFAS exposures (serum concentrations of 9 PFAS). Proxies of cumulative exposures were associated with DNA methylation at 15 CpG sites and one region located within FAM83A (q-value <0.1). SbPFOA was associated with 19 CpG sites (q < 0.1), but due to low detection rates, this PFAS was modeled as detected versus not detected in serum. Overall, there is evidence that firefighting experience is associated with differential DNA methylation in prostate cancer risk loci, but this study did not find evidence that these differences are due to PFAS exposures specifically.

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