2026-03-20 中国科学院（CAS）
＜関連情報＞
- https://english.cas.cn/newsroom/research-news/202603/t20260320_1153043.shtml
- https://www.cell.com/cell/abstract/S0092-8674(26)00230-8
カプセル化されたミトコンドリアの移植は、ミトコンドリア病およびパーキンソン病モデルにおける機能障害を軽減する Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
Shiwei Du ∙ Qi Long ∙ Yanshuang Zhou ∙ … ∙ Hui Zhao ∙ Chenli Liu ∙ Xingguo Liu
Cell Published:March 18, 2026
DOI:https://doi.org/10.1016/j.cell.2026.02.023
Graphical abstract
Highlights
- Highly efficient mitochondrial transplantation via erythrocyte membrane encapsulation
- Mitochondrial transplantation rescues mitochondrial defects in patient-derived cells
- Mitochondrial transplantation rescues mtDNA depletion syndrome and Leigh syndrome
- Mitochondrial transplantation prevents Parkinson’s disease in a mouse model
Summary
Mitochondrial transplantation holds significant potential for the treatment of mitochondrial diseases. However, how to efficiently deliver exogenous mitochondria to somatic cells or tissues remains unresolved. We present a mitochondrial transplantation approach to deliver mitochondria into the cells and tissues of mice and monkeys with high efficiency, based on encapsulating mitochondria with vesicles derived from the plasma membrane of erythrocytes. Treatment with encapsulated mitochondria complemented the loss, deletion, or mutation of mitochondrial DNA, thereby rescuing the associated bioenergetic and biochemical defects in patient-derived cells with mitochondrial disorders. Furthermore, mitochondrial capsules rescued the mitochondrial DNA depletion syndrome and Leigh syndrome in Dguok−/− and Ndufs4−/− mouse models, respectively. Moreover, in a mouse model of Parkinson’s disease, mitochondrial capsules rescued neuron loss, improved motor skills, and restored mitochondrial function in the affected brain regions. Our study demonstrates the potential of this mitochondrial capsule as a treatment for mitochondrial disorders and proposes an “organelle therapy” strategy in regenerative medicine.
