2026-04-23 中国科学院水生生物研究所
＜関連情報＞
- https://english.cas.cn/newsroom/research-news/202604/t20260428_1158199.shtml
- https://link.springer.com/article/10.1007/s11427-026-3272-2
雌性生殖幹細胞をゼブラフィッシュに移植することにより、超高速で雌のみのソウギョを生成 Ultra-fast generation of all-female grass carp via transplantation of female germline stem cells into zebrafish
Ding Ye,Yongkang Hao,Junwen Zhu,Chaofan Wang,Linglu Li,Yongming Li,Yi-Xuan Tu,Zhiqin Ren,Houpeng Wang,Zhengfang Chen,Mudan He,Xiaosi Wang & Yonghua Sun
Science China Life Sciences Published:17 March 2026
DOI:https://doi.org/10.1007/s11427-026-3272-2
Abstract
Surrogate reproduction offers a promising biotechnological approach for accelerating aquaculture breeding. Grass carp (Ctenopharyngodon idellus), a key freshwater species, faces significant constraints in breeding due to its prolonged sexual maturation of 5 years and huge body size. Here, we establish an ultra-fast breeding strategy to generate all-female grass carp within six months via surrogate production in tiny laboratory fish, zebrafish (Danio rerio). We identify and isolate female GSCs from juvenile ovaries of 3-month-old grass carp. Three months after transplantation into zebrafish larvae, the donor-derived female GSCs undergo ultra-fast spermatogenesis and differentiate into functional grass carp sperm carrying X chromosomes. Fertilization of wild-type grass carp eggs with this sperm yields all-female offspring. This work demonstrates that fish female GSCs with XX chromosomes can differentiate into functional sperm in a short time in zebrafish gonadal somatic niche, opening a new avenue for precision breeding and sex control in aquaculture species.
