2026-06-02 スタンフォード大学
＜関連情報＞
- https://news.stanford.edu/stories/2026/06/mechanisms-plant-cell-stability-drought-resistant-crops-research
- https://www.cell.com/cell/abstract/S0092-8674(26)00568-4
植物細胞壁と細胞膜の結合は、セルロース合成酵素複合体とレモリンを介してストレス耐性を媒介する Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins
Yue Rui ∙ Magda Zaoralová ∙ William P. Dwyer ∙ … ∙ Peter D. Dahlberg ∙ Shou-Ling Xu ∙ José R. Dinneny
Cell Published:June 2, 2026
DOI:https://doi.org/10.1016/j.cell.2026.05.009
Graphical abstract
Highlights
- Cell wall-plasma membrane attachments correlate with plant osmotic stress tolerance
- CSC clusters and REM nanodomains localize to wall-membrane attachment sites
- CSC density at the plasma membrane determines the extent of wall-membrane attachment
- REMs rapidly form stress-induced nanodomains and limit CSC density via SHOU4/4L
Summary
The outer cell surface of an organism is the frontline for detecting and responding to environmental stimuli. In plants, this interface consists of the plasma membrane that lies beneath the cell wall and remains associated with it through attachment sites. These wall-membrane attachments become evident upon hyperosmotic shock, when severe water loss causes the membrane to retract from the wall. Despite their long-standing observation, the molecular identity and function of these attachments remain poorly understood. Here, we identified two mechanisms governing wall-membrane attachments: one dependent on the cellulose synthase complex (CSC), whose density at the plasma membrane positively correlates with resistance to hyperosmotic stress, and the other on remorin (REM), which acts antagonistically to the CSC mechanism. Using proximity-labeling proteomics, we identified SHOU4/4L as REM-associated proteins that mediate this antagonism. Together, our findings reveal how wall-membrane attachments are patterned to mediate plant cell resilience under water stress.
