妊娠期ストレスが長期的心血管影響を及ぼすことを確認（UD Study Links Pregnancy Stress to Long-Term Cardiovascular Effects）

2026-06-04

2026-06-03 デラウェア大学（UD）

米国デラウェア大学の研究チームは、妊娠中の合併症が将来の心血管疾患リスクに与える影響について新たな知見を発表した。研究では、妊娠高血圧症候群や妊娠糖尿病などの妊娠関連合併症を経験した女性は、出産後も長期にわたり心血管系への負担が残りやすく、ストレス応答や血管機能の異常を通じて心疾患リスクが高まる可能性が示された。特に心理的・生理的ストレスへの反応が心血管健康に重要な役割を果たしており、妊娠期の健康状態が将来の循環器疾患の早期指標となり得ることが明らかになった。研究者らは、妊娠合併症を単なる一時的な産科上の問題として扱うのではなく、女性の生涯にわたる心血管健康管理の重要なリスク因子として捉える必要があると指摘している。今回の成果は、出産後の継続的な健康モニタリングや予防医療の強化につながる可能性がある。

＜関連情報＞

出産後2～7年におけるストレスの推移と高血圧：nuMoM2b-HHS研究 Stress Trajectory and Hypertension 2 to 7 Years After Delivery: A nuMoM2b-HHS Study

Virginia R. Nuckols, Bethany Barone Gibbs, Benjamin C. Brewer, Allison E. Gaffey, Jody L. Greaney, Freda Patterson, Philip Greenland, … , and Megan M. Wenner
Hypertension Published:9 March 2026
DOI:https://doi.org/10.1161/HYPERTENSIONAHA.125.25991

Graphical Abstract

Abstract

BACKGROUND:

Adverse pregnancy outcomes (APOs) are associated with a higher risk of developing chronic hypertension. The objectives of this study were to determine whether patterns of perceived stress during and after pregnancy were associated with blood pressure and incident hypertension 2 to 7 years after delivery, and whether having an APO modified this association.

METHODS:

Analyses utilized data from the prospective nuMoM2b-HHS cohort (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be Heart Health Study). Perceived stress was assessed using the Perceived Stress Scale in the first and third trimester and 2 to 7 years after delivery. Latent class trajectory analysis characterized subgroups with similar patterns of perceived stress over time. APOs were abstracted from medical charts and included hypertensive disorders of pregnancy, preterm birth, small-for-gestational-age, and stillbirth. Multivariable regression models evaluated the independent effects of perceived stress on systolic and diastolic blood pressure and incident hypertension and 2 to 7 years after delivery.

RESULTS:

Three distinct stress trajectory groups emerged, delineated by persistently low, moderate, and high stress levels. No associations between stress trajectory group and blood pressure or incident hypertension were observed after adjustment for covariates. However, there was a significant interaction between stress trajectory group and APO on blood pressure (P for interaction=0.04). Stress trajectory group was associated with higher blood pressure only among those with APO (β=1.991±0.819 mm Hg; P=0.02) but not without APO (β=0.040±0.471 mm Hg, P=0.93).