2026-07-10 IRCN 東京大学国際高等研究所
統合失調症スペクトラムにおいて淡蒼球外節体積が増大している
＜関連情報＞
- https://ircn.jp/pressrelease/20260710_h-okada_k-kasai
- https://www.nature.com/articles/s41380-026-03729-7
統合失調症スペクトラム連続体における淡蒼球下位領域の役割 The role of the globus pallidus subregions in the schizophrenia spectrum continuum
Naohiro Okada,Kentaro Morita,Shimon Tonsho,Masahiro Kiyota,Eimu Shoji,Daisuke Koshiyama,Shinsuke Koike,Syudo Yamasaki,Atsushi Nishida,Shuntaro Ando,Noriaki Yahata,Kouhei Kamiya,Akira Kunimatsu,Osamu Abe,Sho Yagishita & Kiyoto Kasai
Molecular Psychiatry Published:10 July 2026
DOI:https://doi.org/10.1038/s41380-026-03729-7
Abstract
Within the cortico-basal ganglia network, the volume and functional connectivity (FC) of the globus pallidus (GP) are altered in schizophrenia-spectrum disorders, with GP enlargement being relatively specific to schizophrenia compared to other disorders. However, little is known about alterations in its two major segments, externus (GPe) and internus (GPi), in schizophrenia-spectrum disorders. In this study, we compared GPe/GPi volume and FC between patients with schizophrenia and controls (n > 100), and examined the associations of GPe/GPi volume and FC with subclinical psychotic experiences (SPEs) in early adolescents (n > 200). We found GPe-dominant enlargement and GP subregion-specific FC patterns (e.g., increased left GPe FC with the lateral occipitoparietal area and decreased left GPi FC with the precuneus) in schizophrenia. Additionally, we observed a positive association between GPe volume and SPEs in adolescence, as well as GP subregion-specific FC patterns (e.g., larger left GPe FC with the lingual gyrus) in adolescents with SPEs compared to those without. Future translational studies are needed to elucidate the mechanisms underlying such GP subregion-specific neurophysiological roles.
