2026-07-22 韓国基礎科学研究院（IBS）
Figure 1. Graphical illustration of the meningeal lymphatics lying between the olfactory bulbs near the cribriform plate, and the arachnoid fenestration for CSF outflow. Bottom illustrates the intranasal delivery of VEGF-C vector restoring the lymphatics and CSF outflow in aged mice.
＜関連情報＞
- https://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do?nttId=26921&pageIndex=1&searchCnd=&searchWrd=
- https://www.cell.com/cell/fulltext/S0092-8674(26)00755-5
くも膜窓を通して嗅覚髄膜リンパ管へ脳脊髄液が排出される CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics
Seon Pyo Hong ∙ Cheolhwa Jin ∙ Myung Jin Yang ∙ … ∙ Kari Alitalo ∙ Donald M. McDonald ∙ Gou Young Koh
Cell Published:July 21, 2026
DOI:https://doi.org/10.1016/j.cell.2026.06.035
Highlights
- CSF crosses arachnoid fenestrations and enters dural lymphatics near olfactory bulbs
- Dural lymphatics carrying CSF traverse the cribriform plate and join nasal lymphatics
- Aging reduces arachnoid fenestrations, cribriform plate foramina, olfactory lymphatics, and CSF outflow
- Intranasal VEGF-C normalizes atrophic olfactory lymphatics and impaired CSF outflow
Summary
Meningeal (dural) lymphatics are essential for cerebrospinal fluid (CSF) clearance to cervical lymph nodes, yet the precise pathway is incompletely understood. Using a multifaceted approach in mice, we examined tracer dynamics and the CSF outflow pathway from the subarachnoid space (SAS) to the nasal mucosa and identified a discrete arachnoid region surrounding the olfactory bulbs with abundant fenestrations. Similar arachnoid fenestrations were found in cynomolgus monkeys. Fluorescent tracers in the SAS passed through arachnoid fenestrations into dural lymphatics, which traversed the cribriform plate foramina, joined the nasal lymphatics, and drained to the cervical lymph nodes. In aged mice, the known reduction in CSF outflow was accompanied by lymphatic atrophy in the olfactory dura and nasal mucosa and by fewer arachnoid fenestrations and smaller cribriform plate foramina. Importantly, the lymphatics and CSF clearance were restored to normal by intranasal delivery of vascular endothelial growth factor-C (VEGF-C), thereby documenting the reversibility of the aging-related impairment in CSF clearance.
