2026-08-13 スウォンジー大学
＜関連情報＞
- https://www.swansea.ac.uk/press-office/news-events/news/2026/08/experts-lead-european-study-into-childhood-survival-inequalities.php
- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0352025
先天異常を持つヨーロッパの子供たちの死亡率：EUROLINKCATコホートにおける社会経済的地位との関連性 Mortality amongst European children with congenital anomalies: Associations with socio-economic status in the EUROLINKCAT cohort
Sue Jordan,David Tucker,Ieuan Scanlon,Daniel S. Thayer,Elisa Ballardini,Clara Cavero-Carbonell,Mads Damkjaer,Miriam Gatt,Mika Gissler,Lyubov Ostapchuk,Michel Santoro,Sarah Stevens,Diana Wellesley, [ … ],Hywel T. Evans
PLOS One Published: August 5, 2026
DOI:https://doi.org/10.1371/journal.pone.0352025
Abstract
Background
Childhood mortality is affected by major congenital anomalies and socio-economic status (SES). To our knowledge, their combined impact has not been explored to age 10.
Methods
We analysed the population-based EUROlinkCAT cohort to ascertain the impact of SES on mortality by ages 1 and 10 amongst children with congenital anomalies in ten congenital anomaly registers in seven European countries. Four countries defined SES according to maternal education, and two used their national index of multiple deprivation. The ten registers used a common script to generate data on survival by ages 1 and 1–10 (365–3651 days). Eight registers analysed deaths according to their SES criteria, categorised as low, intermediate and high SES. Linked data were combined in random effects meta-analyses. Finland and Emilia-Romagna held data on single motherhood and EU-nationality.
Results
We analysed mortality in relation to SES using data on 47,134 live-born children with major congenital anomalies classified and recorded 1996–2014. Mortality by age 1 and ages 1–10 was higher amongst the most than the least deprived, hazard ratios (HR) and 95% confidence intervals (CI) 1.47, 1.19–1.83 and 2.00, 1.32–3.02. Differences between intermediate and least deprived groups were smaller. Differences were statistically significant for all four analyses only in Ukraine and Wales. Mortality rates were higher for children of non-EU nationals, but not single mothers.
Implications
Deprivation was more strongly associated with death at ages 1–10 than in infancy. These analyses of the most ill children in Europe indicate that, to achieve sustainable development goals, more resources are needed for the most vulnerable children.
