非侵襲的な技術で早産を解明できる可能性がある Noninvasive technique could shed light on preterm birth
2023-03-14 ワシントン大学セントルイス校
この技術により、妊娠高リスクの患者のケアの改善や、世界的に妊娠の約10%で発生する早産の予防方法の特定に役立つと考えられている。今後は、正常な子宮収縮の測定を通じて、子宮収縮が出産につながるかどうかを明らかにする予定だ。また、経済的に余裕がない地域でも使えるよう、MRIスキャンの代わりに安価で携帯性の高い超音波イメージングを使用することを目指している。
<関連情報>
- https://source.wustl.edu/2023/03/imaging-tech-produces-real-time-3d-maps-of-uterine-contractions-during-labor/
- https://medicine.wustl.edu/news/imaging-technology-produces-real-time-3d-maps-of-uterine-contractions-during-labor/
- https://www.nature.com/articles/s41467-023-36440-0
正期産におけるヒトの子宮成熟の非侵襲的筋電図法イメージング Noninvasive electromyometrial imaging of human uterine maturation during term labor
Hui Wang,Zichao Wen,Wenjie Wu,Zhexian Sun,Zulfia Kisrieva-Ware,Yiqi Lin,Sicheng Wang,Hansong Gao,Haonan Xu,Peinan Zhao,Qing Wang,George A. Macones,Alan L. Schwartz,Phillip Cuculich,Alison G. Cahill & Yong Wang
Nature Communications Published:14 March 2023
DOI:https://doi.org/10.1038/s41467-023-36440-0
Abstract
Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects’ clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.
