2024-07-17 ã«ãªãã©ã«ãã¢å€§åŠãªããŒãµã€ãæ ¡(UCR)
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- https://news.ucr.edu/articles/2024/07/17/microbes-found-destroy-certain-forever-chemicals
- https://www.science.org/doi/10.1126/sciadv.ado2957
ã¢ã»ããã¯ããªãŠã å±çŽ°èã«ãããã«ãã«ãªãäžé£œåã«ã«ãã³é žã®è±ããçŽ ã«é¢äžããé»ååå²ç³»ãšããåç©æåºç³» Electron bifurcation and fluoride efflux systems implicated in defluorination of perfluorinated unsaturated carboxylic acids by Acetobacterium spp
YAOCHUN YU, FENGJUN XU, WEIYANG ZHAO, CALVIN THOMA , […], AND YUJIE MEN
Science Advances Published:17 Jul 2024
DOI:https://doi.org/10.1126/sciadv.ado2957
Abstract
Enzymatic cleavage of CâF bonds in per- and polyfluoroalkyl substances (PFAS) is largely unknown but avidly sought to promote systems biology for PFAS bioremediation. Here, we report the reductive defluorination of α, β-unsaturated per- and polyfluorocarboxylic acids by Acetobacterium spp. The microbial defluorination products were structurally confirmed and showed regiospecificity and stereospecificity, consistent with their formation by enzymatic reactions. A comparison of defluorination activities among several Acetobacterium species indicated that a functional fluoride exporter was required for the detoxification of the released fluoride. Results from both in vivo inhibition tests and in silico enzyme modeling suggested the involvement of enzymes of the flavin-based electron-bifurcating caffeate reduction pathway [caffeoyl-CoA reductase (CarABCDE)] in the reductive defluorination. This is a report on specific microorganisms carrying out enzymatic reductive defluorination of PFAS, which could be linked to electron-bifurcating reductases that are environmentally widespread.
