人間の心臓には自己修復能力が秘められているかもしれない(The human heart may have a hidden ability to repair itself)

2024-11-21 カロリンスカ研究所(KI)

Photo: Pixabay

<関連情報>

• https://news.ki.se/the-human-heart-may-have-a-hidden-ability-to-repair-itself
• https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067156

ヒトの心臓病における潜在的な心筋細胞再生の可能性 A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease

Wouter Derks, Julian Rode , Sofia Collin, Fabian Rost , Paula Heinke , Anjana Hariharan, Lauren Pickel , …, and Olaf Bergmann
Circulation  Published: 21 November 2024
DOI:https://doi.org/10.1161/CIRCULATIONAHA.123.067156

Abstract

BACKGROUND:
Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.

METHODS:
We determined cardiomyocyte renewal in 52 patients with advanced heart failure, 28 of whom received left ventricular assist device support. We measured the concentration of nuclear bomb test–derived ¹⁴C in cardiomyocyte genomic DNA and performed mathematical modeling to establish cardiomyocyte renewal in heart failure with and without LVAD unloading.

RESULTS:
We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18 to 50× lower compared with the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart.

CONCLUSIONS:
Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.