2026-02-26 東北大学
図1. IBD患者はヒト最大の免疫組織である腸管免疫が破綻し、腸炎の発症だけでなく皮膚、粘膜、関節など、全身の免疫機能が低下する。根尖性歯周炎は歯の根の先端の骨における感染防御反応によって発生するが、基礎疾患を抱えた宿主の免疫機能の影響をどのように受けているかまだ明らかでなかった。
＜関連情報＞
- https://www.tohoku.ac.jp/japanese/2026/02/press20260226-01-IBD.html
- https://www.tohoku.ac.jp/japanese/newimg/pressimg/tohokuuniv-press20260226_web01_IBD.pdf
- https://journals.sagepub.com/doi/10.1177/00220345251412776
炎症性腸疾患によって悪化する根尖性歯周炎を標的とする新しい方法 Novel Method to Target Apical Periodontitis Worsened by Inflammatory Bowel Disease
M. Nakano, Y. Tanaka, […], and M. Saito
Journal of dental research Published:February 24, 2026
DOI:https://doi.org/10.1177/00220345251412776
Abstract
Patients with inflammatory bowel disease (IBD) have a higher prevalence of apical periodontitis (AP), which is often associated with accelerated jawbone destruction. However, the mechanisms underlying this exacerbation remain unclear. In this study, we established a colitis+AP model and demonstrated that colitis exacerbates alveolar bone destruction. The upregulation of genes related to inflammation and neutrophils was also observed in the colitis+AP model compared with the AP-only model. In addition, colitis-induced local neutrophil infiltration was observed in the alveolar bone, which was further amplified by bacterial infection originating from the root canal. To address the exacerbated bone destruction in colitis+AP, we used a novel laser-induced cavitation system to locally deliver the immunosuppressant tacrolimus into the jawbone. This targeted approach effectively suppressed alveolar bone loss in the colitis+AP model. Our findings highlight the importance of the inflammatory interplay between IBD and AP. Systemic inflammation caused by IBD weakens local neutrophil function, leading to increased bone destruction and treatment-resistant AP. Furthermore, laser-activated local administration of tacrolimus significantly ameliorated bone destruction in AP associated with colitis.
