2026-04-23 カリフォルニア大学アーバイン校（UCI）
＜関連情報＞
- https://news.uci.edu/2026/04/23/dopamine-deficiency-found-to-drive-memory-impairment-in-alzheimers-disease/
- https://www.nature.com/articles/s41593-026-02260-w
アルツハイマー病ノックインモデルにおける内嗅皮質のドーパミンの初期障害 Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer’s disease
Tatsuki Nakagawa,Jiayun L. Xie,Kiwon Park,Kai Cao,Marjan Savadkohighodjanaki,Yutian J. Zhang,Heechul Jun,Ayana Ichii,Jason Y. Lee,Shogo Soma,Yasmeen K. Medhat,Takaomi C. Saido & Kei M. Igarashi
Nature Neuroscience Published:23 April 2026
DOI:https://doi.org/10.1038/s41593-026-02260-w
Abstract
The entorhinal cortex is a critical brain area for memory formation, while also the region exhibiting the earliest histological and functional alterations in Alzheimer’s disease (AD). The entorhinal cortex therefore has been long hypothesized as one of the originating brain areas of AD pathophysiology, although circuit mechanisms causing its selective vulnerability remain poorly understood. Here we show that dopamine neurons projecting their axons to the lateral entorhinal cortex (LEC), critical for memory formation in healthy brains, become dysfunctional from the early pathological stage and cause associative memory impairments in amyloid precursor protein knock-in mice. Dopamine dysfunction led to the disruption of associative memory encoding of LEC layer 2/3. Optogenetic reactivation of LEC dopamine fibers rescued associative learning behavior. L-DOPA treatment restored memory encoding of LEC neurons and associative memory of amyloid precursor protein knock-in mice. These results suggest early dysfunction of LEC-projecting dopamine neurons underlie memory impairment in AD from early stages, pointing to a need for clinical investigation of LEC dopamine in patients with AD.
