2026-06-05 九州大学
＜関連情報＞
- https://www.kyushu-u.ac.jp/ja/researches/view/1495
- https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70371
APOE ε4、修正可能な危険因子、および地域在住の日本人高齢者における認知症 APOE ε4, modifiable risk factors, and dementia in community-based older Japanese adults
Masaya Kumamoto, Toshiharu Ninomiya, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Tetsuro Ago, Yasuyuki Taki, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Ritsuko Hanajima, Jun-ichi Iga, Minoru Takebayashi, Yukihide Momozawa, the Japan Prospective Studies for Aging and Dementia (JPSC-AD) Study Group
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Published: 21 May 2026
DOI:https://doi.org/10.1002/dad2.70371
Abstract
INTRODUCTION
Apolipoprotein E (APOE) ε4 is a major genetic risk factor for dementia. We examined whether APOE ε4 genotype modified the associations between a modifiable risk factor (mRF) score and dementia in older Japanese adults.
METHODS
This cross-sectional study included 9605 community-dwelling Japanese individuals aged ≥65 years. APOE ε4 genotype and mRF scores were assessed. Dementia was clinically diagnosed. Brain magnetic resonance imaging (MRI) measures were available in a subset.
RESULTS
The odds ratio (OR) for dementia increased with the number of APOE ε4 alleles. A low mRF score was associated with lower ORs for prevalent dementia in non-carriers and heterozygotes but not in homozygotes. On MRI, low mRF scores were associated with preserved brain structure in non-carriers and heterozygotes, but not in homozygotes.
DISCUSSION
Favorable risk factor profiles were associated with lower dementia risk and preserved brain structure in APOE ε4 non-carriers and heterozygotes, but not in homozygotes, supporting genotype-tailored prevention strategies.
Highlights
- APOE ε4 homozygotes had over 10-fold higher dementia odds than non-carriers.
- Non-carriers and heterozygotes with a favorable risk factor profile had lower dementia risk.
- APOE ε4 homozygotes showed high dementia risk regardless of risk profile.
- Favorable risk factor profiles preserved brain structure in non-carrier and heterozygotes, but not homozygotes.
