パーキンソン病患者では皮質レビー病理がほとんど認められないことを報告（Study Finds Little to No Cortical Lewy Pathology in Living Parkinson’s Disease Patients Undergoing Deep Brain Stimulation）

2026-07-01 マウントサイナイ医療システム（MSHS）

Credit: Ariela Buxbaum Grice, graduate student at the Icahn School of Medicine at Mount Sinai and lead author of the study.

＜関連情報＞

• https://www.mountsinai.org/about/newsroom/2026/studyfinds-little-to-no-cortical-lewy-pathology-in-living-parkinsons-disease-patients-undergoing-deep-brain-stimulation
• https://www.nature.com/articles/s41531-026-01422-8

深部脳刺激療法を受けているパーキンソン病患者の前頭前皮質には、レビー小体病理はほとんど見られない Lewy pathology largely absent in prefrontal cortices of Parkinson’s disease patients undergoing deep brain stimulation

Ariela S. Buxbaum Grice,Brian H. Kopell,Klaudia F. Laborc,Anina N. Lund,Renata Gonzalez Chong,Meredith Spadaccia,Gerard Ona,Girish Nadkarni,John F. Crary,Alexander W. Charney & Noam D. Beckmann
npj Parkinson’s Disease  Published:01 July 2026
DOI:https://doi.org/10.1038/s41531-026-01422-8

Abstract

Parkinson’s disease (PD) patients undergo deep brain stimulation (DBS) when other treatments are insufficient. Given the patients’ advanced clinical stage, an advanced neuropathological stage is assumed. We examined Lewy pathology in prefrontal cortices (PFCs) of DBS recipients. Virtually no Lewy pathology was seen in PD biopsies. In contrast, postmortem PD PFC samples showed significantly greater Lewy pathology than controls. Thus, DBS patients may be less neuropathologically advanced in progression than previously thought.