2026-08-24 中国科学院（CAS）
＜関連情報＞
- https://english.cas.cn/newsroom/research-news/202608/t20260821_1188663.shtml
- https://www.cell.com/cell/fulltext/S0092-8674(26)00639-2
リンパ管は疾患時には骨に侵入するが、健康状態や再生時には存在しない Lymphatic vessels invade bone in disease but are absent in health and regeneration
Xinfeng Meng ∙ Kuo Liu ∙ Muxue Tang ∙ … ∙ Kai Kruse ∙ Ralf H. Adams ∙ Bin Zhou
Cell Published:Published: August 20, 2026
DOI:https://doi.org/10.1016/j.cell.2026.05.039
Highlights
- Specific genetic tools reveal the absence of LECs in bone during homeostasis
- Bone regeneration after irradiation does not trigger LEC emergence inside the bone
- LECs expand within the callus but do not infiltrate the bone after fracture
- LECs invade bone under pathological conditions in GLA/GSD mouse models
Summary
A recent study reported the existence of lymphatic vessels in normal bone and suggested their involvement in bone regeneration after injury. However, this conclusion was based on approaches that do not allow unequivocal identification of the spatial localization of lymphatic endothelial cells (LECs). Here, we employed a Prox1-based genetic tool and a dual-recombinase-mediated LEC-specific labeling system to trace lymphatic vessels with high specificity. We found that LECs are present in the connective tissues, including the periosteum surrounding the bone. However, they do not reside within the bone itself, nor do they penetrate the periosteum to facilitate bone regeneration after injury. By contrast, hyperplastic LECs on the bone surface breach the periosteum and invade bone tissue in mouse models of generalized lymphatic anomaly and Gorham-Stout disease. These data demonstrate that lymphatic vessels are absent from bone during homeostasis and regeneration after injury but invade bone during disease. This Matters Arising paper is in response to Biswas et al. (2023), published in Cell. See also the response by Yang et al. (2026), published in this issue.
